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Macedonian Veterinary Review


p-ISSN 1409-7621
e-ISSN 1857-7415

Co-publishing with:
De Gruyter

Abstract / References

Review Article
Published on: 15 October 2018

The oocyte´s nucleolus precursor body: The globe for life
Michal Benc1,2, Lazo Pendovski3, Matej Murin4, Frantisek Strejcek4, Martin Morovic4, Radek Prochazka5, Jozef Laurincik1,5
1Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, Nabrezie mladeze 91, 949 74 Nitra, Slovak Republic
2Institute of Animal Science, Pratelstvi 815, 104 00 Prague - Uhrineves, Czech Republic
3Ss. Cyril and Methodius University in Skopje, Lazar Pop - Trajkov 5-7, 1000 Skopje, Republic of Macedonia
4Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, Nabrezie mladeze 91, 949 74 Nitra, Slovak Republic
5The Czech Academy of Sciences, Institute of Animal Physiology and Genetics, Rumburska 89, 277 21 Libechov, Czech Republic


The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into a dense sphere with no ribosome synthesis well in advance of ovulation. It seems, that this body is of utmost importance for the development of the embryo. It is unknown, however, how it exerts this essential function. During the last two decades, great attention has been paid to the study of nucleogenesis in oocytes and early embryos, with transcription of ribosomal DNA being evaluated as one of the criteria of normal development. In this review, we summarize some aspects of nucleolus transformation during oocyte growth, as well as during early embryonic development with possible impact on the quality of the embryos used in biomedical research. This knowledge in connection with further observations will substantially contribute to the development of new criteria suitable for evaluation of oocytes and embryos used in biomedical application.
Key words: nucleolus precursor body, oocyte, embryo, transcriptomics, epigenetics

Mac Vet Rev 2018; 41 (2):115-122
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Available Online First: 31 March 2018

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