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Macedonian Veterinary Review


p-ISSN 1409-7621
e-ISSN 1857-7415

Co-publishing with:
De Gruyter

Abstract / References

Short Communication

Acute oral toxicity of Vetom 21.77 based on DuddingtoniaFlagrans in broiler chickens
Elmira R. Rafikova
Department of Pharmacology and General Pathology, Faculty of Veterinary Medicine, Novosibirsk State Agrarian University, 630039 Dobrolubova 160, Novosibirsk, Russian Federation


A 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus Duddingtonia flagrans. A total of 40 healthy 5-day-old broiler chickens (Hubbard F15, 100 ± 5 g), that had previously gone through a required 5-days adaptation to the environment, were orally dosed with the drug for 5 consecutive days at different doses, after which their health status was assessed daily up to the end of the experiment. According to the results, no substantial changes in the physiological state of the chickens were detected during the experiment. Internal organs weighing revealed no statistically significant differences between the groups, though weight coefficient values of internal organs of treated chickens slightly exceeded those of the control group. Some haematological parameters were significantly higher in the treatment group, without going beyond reference ranges. All chickens used in the experiment survived the study. The preparation has not produced any toxic effect even at a higher dose (4000 μL/kg bw/day). It is concluded that Vetom 21.77 pertains to preparations of IV toxicity class.
Key words: Vetom 21.77, Duddingtonia flagrans, acute toxicity, Hubbard F15

Mac Vet Rev 2019; 42 (1): i-vii
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Available Online First: 30 December 2018

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