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Macedonian Veterinary Review


p-ISSN 1409-7621
e-ISSN 1857-7415

Co-publishing with:
De Gruyter

Abstract / References

Case Report

Mammary adenocarcinoma with widespread metastasis in a lion (Panthera leo)
Ivica Gjurovski1, Monika Dovenska1, Slavica Kostadinova Kunovska2, Jordanco Milosevski3, Vesna Levajkovic Trajkov3, Trpe Ristoski1
1Faculty of Veterinary Medicine, University “Ss Cyril and Methodius”, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of North Macedonia
2Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of North Macedonia
3Zoo Garden Skopje, Republic of North Macedonia


A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.
Key words: carcinoma, mammary gland, lion

Mac Vet Rev 2019; 42 (2): i-ix
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