REVIEW_ARTICLE Impact of recurrent airway obstruction (RAO) on selected antioxidants in horses The aim of this review was to collect the most important data on the characteristics of selected antioxidants in horses with recurrent airway obstruction (RAO). RAO is one of the most common respiratory diseases in horses. This disease can not be cured, but we can try to stop its progression. It is not exactly known, what is the real contribution of antioxidants in the pathology of recurrent airway obstruction. Many researchers investigated the possibility of using antioxidant supplementation in horses with RAO. https://macvetrev.mk 2016-03-15T09:00:00 5 14 10.2478/macvetrev-2016-0074 recurrent airway obstruction antioxidants horses Hieronim Borowicz false 1 Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland AUTHOR Krzysztof Kubiak false 2 Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland AUTHOR Goran Nikolovski false 3 Department of Internal Diseases for Pet Animals and Equides, Faculty of Veterinary Medicine, Lazar Pop Trajkov 5-7, 1000 Skopje, Macedonia AUTHOR Artur Niedźwiedź artur.niedzwiedz@up.wroc.pl false 4 Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland LEAD_AUTHOR Niedźwiedź, A., Nicpoń, J., Różycki, P. (2006). Pathogenesis, diagnosis and treatment of Recurrent Equine Airway. Med. Wet. 5, 512-515. 1 McPherson, E. A., Lawson, G. H., Murphy, J. R., Nicholson, J. M., Fraser, J. A., Breeze, R. G., Pirine, H. M. (1978). Chronic obstructive pulmonary disease (COPD) identification of affected horses. Equine Vet. J. 10, 47-53. PMid:631106 2 10.1111/j.2042-3306.1978.tb02215.x Niedźwiedź, A, Jaworski, Z, Kubiak, K. (2014). Circulating immune complexes and markers of systemic inflammation in RAO-affected horses. Pol. J. Vet. Sci. 17, 697-702. 3 10.2478/pjvs-2014-0101 Commoner, B., Townsend, J., Pake, G. E. (1954). Free radicals in biological materials. Nature 174, 689-691. PMid:13213980 4 10.1038/174689a0 Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300. PMid:13332224 5 10.1093/geronj/11.3.298 Bannister, W. H. (1988). From haemocuprein to copper-zinc superoxide dismutase: a history on the fiftieth anniversary of the discovery of haemocuprein and the twentieth anniversary of the discovery of superoxide dismutase. Free Radic. Res. Commun. 5, 35-42. PMid:3069613 6 10.3109/10715768809068556 Zawadzki, M., Pawlas, K., Niedźwiedź, A., Murawska-Ciałowicz, E., Januszewska, L., Nicpoń, J. (2008). Ewaluation of oxidative stress in manganum intoxication rat’s barins. Medycyna Wet. 6, 836-840. 7 Chelikani, P., Fita, I., Loewen, P.C. (2004). Diversity of structures and properties among catalases. Cellular and Molecular Life Sciences 61, 192–208. PMid:14745498 8 10.1007/s00018-003-3206-5 Cadenas E. (1997). Basic mechanism of antioxidant activity. BioFactors 6: 391-397. 9 Epp, O., Ladenstein, R., Wendel, A. (1983). The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution. Eur. J. Biochem. 133, 51–69. PMid:6852035 10 10.1111/j.1432-1033.1983.tb07429.x Heffner, J. E., Repine, J. E. (1989). Pulmonary strategies of antioxidant defense. Am. Rev. Respir:. Dis. 140, 531-554. PMid:2669581 11 10.1164/ajrccm/140.2.531 Baldwin, S. R., Grum, C. M., Boxer, L. A., Simon, R. H., Ketai, L. H., Devall, L. H. (1986). Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1, 11-13. 12 10.1016/S0140-6736(86)91895-7 Barnes, P. J. (1990). Reactive oxygen species and airway inflammation. Free Radic. Biol. Med. 9, 235-243. 13 10.1016/0891-5849(90)90034-G Cantin, A.M., Crystal, R.G. (1985). Oxidants, antioxidants and the pathogenesis of emphysema. Eur: J. Respi. Dis. 66, 7-17. 14 Kirschvink, N., Reinhold, P. (2008). Use of alternative animals as asthma models. Curr Drug Targets 9, 470-484. PMid:18537586 15 10.2174/138945008784533525 Art, T., Kirschvink, N., Smith, N., Lekeux, P. (1999). Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine. Vet. J. 31, 397–401. PMid:10505955 16 10.1111/j.2042-3306.1999.tb03839.x Kirschvink, N., Smith, N., Fievez, L. (2002). Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses. Equine Vet. J. 34, 563–571. PMid:12357995 17 10.2746/042516402776180223 Niedźwiedź, A., Jaworski, Z. (2014). Oxidant-antioxidant status in the blood of horses with symptomatic recurrent airway obstruction (RAO). J. Vet. Intern. Med. 28, 1845–1852. PMid:25231643 18 10.1111/jvim.12452 Art, T., Kirschvink, N., Smith, N., Lekeux, P. (1999). Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet. J. 31, 397-401. PMid:10505955 19 10.1111/j.2042-3306.1999.tb03839.x Olszweski, M. A., Laber, G. (1993). Production of free oxygen radicals by phagocytes from respiratory tract lavaged as well as from peripheral blood of horses with Chronic Obstructive Pulmonary Disease (COPD) in comparison to healthy animals. Wien. Tierdrztl. Msch. 332-337. 20 Klaveren, R. J. van Demedts, M., Nemery, B. (1997). Cellular glutathione turnover in vitro, with emphasis on type 11 pneumocytes. Eu. Respir. J. 10, 1392-1400. 21 10.1183/09031936.97.10061392 Kirschvink, N., Smith, N., Fievez, L., Bougnet, V., Art, T., Degand, G., Marlin, D., Roberts, C., Genicot, B., Lindsey, P., Lekeux, P. (2002). Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses. Equine Vet. J. 34, 563-571. PMid:12357995 22 10.2746/042516402776180223 Harris, R. C., Marlin, D. J., Snow, D. H., Harkness, R. A. (1991). Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse. Eur. J. Appl. Physiol. 62, 235-244. 23 10.1007/BF00571546 Rahman, I., Swarska, E., Henry, M., Stolk, J., MacNee, W. (2000). Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 55, 189-193. PMid:10679536 PMCid:PMC1745692 24 10.1136/thorax.55.3.189 Smith, L. J., Houston, M., Anderson, J. (1993). Increased levels of glutathione in bronchoalveolar lavage fluid from patients with asthma. Am. Rev. Respir. Dis. 147, 1461-1464. PMid:8503557 25 10.1164/ajrccm/147.6_Pt_1.1461 Kodavanti, U. P., Costa, D. L., Richards, J., Crissman, K. M., Slade, R., Hatch, G. E. (1996). Antioxidants in bronchoalveolar lavage fluid cells isolated from ozoneexposed normal and ascorbate-deficient guinea pigs. Expt. Lung Res. 22, 435-448. 26 10.3109/01902149609046034 Rautalahti, M., Virtamo, J., Haukka, J., Heinonen, O.P., Sundvall, J., Albanes, D., Huttunen, J.K. (1997). The effect of alpha-tocopherol and beta-carotene supplementation on COPD symptoms. Am. J. Respir. Crit. Care Med. 156, 1447-1452. PMid:9372659 27 10.1164/ajrccm.156.5.96-11048 Grievink, L., Smit, H.A., Ocké, M.C., van t’Veer, P., Kromhout, D. (1998). Dietary intake of antioxidant (pro-) vitamins, respiratory symptoms and pulmonary function: the MORGEN study. Thorax 53, 166-171. PMid:9659349 PMCid:PMC1745167 28 10.1136/thx.53.3.166 MacNee, W., Rahman, I. (1999). Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160, 58-65. PMid:10556172 29 10.1164/ajrccm.160.supplement_1.15 Forastiere, F., Pistelli, R., Sestini, P., Fortes, C., Renzoni, E., Rusconi, F., Dell’Orco, V., Ciccone, G., Bisanti, L. (2000). Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. SIDRIA Collaborative Group, Italy (Italian Studies on Respiratory Disorders in Children and the Environment). Thorax 55, 283-288. PMCid:PMC1745721 30 10.1136/thorax.55.4.283 Kirschvink, N., Fievez, L., Bougnet, V., Art, T., Degand, G., Smith, N., Marlin, D., Roberts, C., Harris, P., Lekeux, P. (2002). Effect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves-affected horses. Equine Vet J. 34, 705-712. PMid:12455842 31 10.2746/042516402776250298 Essén-Gustavsson, B., Gottlieb-Vedi, M., Lindholm, A. (1999). Muscle adenine nucleotide degradation during submaximal treadmill exercise to fatigue. Equine Vet J. Suppl. 30, 298-302. PMid:10659272 32 Mills, P.C., Smith, N.C., Harris, R.C., Harris, P. (1997). Effect of allopurinol on the formation of reactive oxygen species during intense exercise in the horse. Res Vet Sci. 62, 11-16. 33 10.1016/S0034-5288(97)90172-7 Heunks, L.M.A., Vina, J., van Herwaarden, C.L., Folgering, H.T.M., Gimeno, A., Dekhuijzen, P.N. (1999). Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am. J. Physiol. 277, 1697-1704. 34 Youssef, M.A., El-khodery, S.A., Ibrahim, H.M. (2013). Effect of selenium and vitamin c on clinical outcomes, trace element status, and antioxidant enzyme activity in horses with acute and chronic lower airway disease. A randomized clinical trial. Biol Trace Elem Res. 152, 333–342. PMid:23479319 35 10.1007/s12011-013-9636-5 Kirschvink, N., de Moffarts, B., Lekeux, P. (2008). The oxidant/antioxidant equilibrium in horses. Vet J. 177, 178–191. PMid:17897849 36 10.1016/j.tvjl.2007.07.033 Jain, SK, Mcvie, R, Smith, T. (2000). Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. Diabetes Care 23, 1389–1394. PMid:10977039 37 10.2337/diacare.23.9.1389 Johnson, K. (2006). Effects of vitamin E supplementation on oxidative stress parameters measured in exercising horses. Doctoral dissertation. University of Florida 38 Matera, M.G., Calzetta, L., Peli, A., Scagliarini, A., Matera, C., Cazzola, M. (2005). Immune sensitization of equine bronchus: glutathione, IL-1 expression and tissue responsiveness. Respiratory Research 6, 104. PMid:16164745 PMCid:PMC1261534 39 10.1186/1465-9921-6-104 Rahman, I., MacNee, W. (2000). Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med. 28:, 1405-1420. 40 10.1016/S0891-5849(00)00215-X Rahman, I. (2002). Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. Curr Drug Targets Inflamm Allergy, 1, 291-315. PMid:14561194 41 10.2174/1568010023344607 Vengopual, C., Mariappan, N., Holmes, E., Kearney, M., Beadle, R. (2013). Effect of potential therapeutic agents in reducing oxidative stress in pulmonary tissues of recurrent airway obstruction-affected and clinically healthy horses Equine Vet J. 45, 80–84. PMid:22506732 42 10.1111/j.2042-3306.2012.00566.x Cortijo, J., Bou, J., Beleta, J., Cardelus, I., Llenas, J., Morcillo, E., Gristwood, R.W. (1993). Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br. J. Pharmacol. 108, 562-568. PMid:8383567 PMCid:PMC1907986 43 10.1111/j.1476-5381.1993.tb12841.x Zhang, J., Xu, Z., Zhang, C., Dail, H., Jil, X., Wang, X., Lil, C. (2011). Pyrrolidine dithiocarbamate inhibits nuclear factor-kB pathway activation, and regulates adhesion, migration, invasion and apoptosis of endometriotic stromal cells. Mol Hum Reprod. 17, 175-181. PMid:21030494 44 10.1093/molehr/gaq090 Granström, B.W., Xu, C.B., Nilsson, E., Bengtsson, U.H., Edvinsson, L. (2004). Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. Basic Clin Pharmacol Toxicol. 95, 43-48. PMid:15245576 45 10.1111/j.1742-7843.2004.pto950109.x Hay, D.W., Goldie, R.G. (1998). Potential pathophysiological role of endothelin-1 in asthma. Drug News Perspect 11, 411-418. PMid:15616682 46 10.1358/dnp.1998.11.7.660500 Leguillette, R., Desevaux, C., Lavoie, J. (2002). Effects of pentoxifylline on pulmonary function and results of cytological examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction. Am J Vet Med. 63, 459-463. 47 Mudway, I. S., Krishna, M. T., Frew, A. J. et al. (1999). Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone. Occup Environ Med. 56, 473–481. PMid:10472319 PMCid:PMC1757764 48 10.1136/oem.56.7.473 Thomas, E. L., Learn, D. B., Jefferson, M. M. (1999). Superoxidedependent oxidation of extracellular reducing agents by isolated neutrophils. J Biol Chem. 263, 2178–2186. 49 Bielory, L., Gandhi, R. (1994). Asthma and vitamin C. Ann Allergy 73, 89–96. PMid:8067602 50 Schunemann, H. J., Freudenheim, J. L., Grant, B.J. (2001). Epidemiologic evidence linking antioxidant vitamins to pulmonary function and airway obstruction. Epidemiol Rev. 23, 248–267. PMid:12192736 51 10.1093/oxfordjournals.epirev.a000805 Deaton, C. M., Marlin, D. J., Smith, N. C., Harris, P. A., Roberts, C. A., Schroter, R. C., Kelly, F. J. (2004). Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. AJVR 65, 80-87. 52 10.2460/ajvr.2004.65.80 Bigley, R. H., Stankova, L. (1974). Uptake and reduction of oxidized and reduced ascorbate by human leukocytes. J. Exp. Med. 139, 1084–1092. PMid:4825242 PMCid:PMC2139671 53 10.1084/jem.139.5.1084 Mudway, I.S., Kelly, F.J. (2000). Ozone and the lung: a sensitive issue. Mol Aspects Med. 21, 1-48. 54 10.1016/S0098-2997(00)00003-0 Pryor, W. A., Das,. B., Church, D. F. (1991). The ozonation of unsaturated fatty acids: aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity. Chem. Res. Toxicol. 4, 341-348. PMid:1912318 55 10.1021/tx00021a014 Deaton, C. M., Marlin, D. J., Smith, N. C., Roberts, C. A. , Harris, P. A. , Schroter, R. C., Kelly, F. J. (2005). Antioxidant and inflammatory responses of healthy horses and horses affected by recurrent airway obstruction to inhaled ozone. Equine Vet J. 37, 243-249. PMid:15892234 56 10.2746/0425164054530605 Kari, F., Hatch, G., Slade, R., Crissman, K., Simeonova, P.P., Luster, M. (1997). Dietary restriction mitigates ozone-induced lung inflammation in rats: a role for endogenous antioxidants. Am J Respir Cell Mol Biol. 17, 740-747. PMid:9409561 57 10.1165/ajrcmb.17.6.2844 Long, N. C., Suh, J., Morrow, J. D., Schiestl, R. H., Murthy, G. G., Brain, J. D., Frei, B. (2001). Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters. J. Appl. Physiol. 91, 1694-1700. PMid:11568152 58 Krawisz, J. E., Sharon, P., Stenson, W. F. (1984). Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87, 1344–1350. PMid:6092199 59 Weiland, J. E., Davis, W. B., Holter, J. F., Mohammed, J. R., Dorinsky, P. M., Gadek, J. E. (1986). Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Respir Dis. 133, 218–225. 60 Art, T., Franck, T., Lekeux, P., de Moffarts, B., Couëtil, L., Becker, M., Kohnen, S., Deby-Dupont, G., Serteyn, D. (2006). Myeloperoxidase concentration in bronchoalveolar lavage fluid from healthy horses and those with recurrent airway obstruction. The Canadian Journal of Veterinary Research 70, 291–296. PMid:17042382 PMCid:PMC1562538 61 Niedźwiedź, A., Filipowski, H., Służewska-Niedźwiedź, M., Nicpoń, J. (2011). Stress level in horses during transport as a variable in Krefft’s function. Medycyna Wet. 67, 270-274. 62 Niedźwiedź, A., Nicpoń, J., Zawadzki, M., Słuzewska-Niedźwiedź, M., Januszewska, L. (2012). The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes. Vet Clin Pathol. 41, 123-126. 63 10.1111/j.1939-165x.2011.00396.x Niedźwiedź, A., Nicpoń, J., Borowicz, H, Łoś, P., Zawadzki, M., Januszewska, L. (2011). Evaluation of selected antioxidant enzymes in the blood of horses with recurrent airways obstruction. Medycyna Wet. 67, 129-132. 64 Tan, R.H., Thatcher, C.D., Buechner-Maxwell, V., Christmann, U., Crisman, M.V., Were, S.R., (2010). Measurement of ascorbic acid concentration and glutathione peroxidase activity in biological samples collected from horses with recurrent airway obstruction. Am J Vet Res. 71, 1500-1507. PMid:21118003 65 10.2460/ajvr.71.12.1500 Ramery, E., Fraipont, A., Richard, E.A., Art, T., Pirottin, D., van Delm, W., Bureau, F., Lekeux, P. (2015). Expression microarray as a tool to identify differentially expressed genes in horses suffering from inflammatory airway disease. Vet Clin Pathol. 44, 37–46. PMid:25488254 66 10.1111/vcp.12216 Quinlan, T., Spivack, S., Mossman, B.T. (1994). Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Perspect. 102, 79–87. PMid:7523104 PMCid:PMC1567078 67 10.1289/ehp.9410279 Dumitrascu, R., Heitmann, J., Seeger, W., Weissmann, N., Schulz, R. (2013). Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies. Oxid Med Cell Longev. PMid:23533685 PMCid:PMC3603718 68 10.1155/2013/234631