SCIENTIFIC_REVIEW The illegal poisoning of dogs and other domestic and wild animals presents a worldwide problem causing animal suffering and R. Macedonia is not an exeption. The goal of this study is to make a comparison of the results from the histopathological examination conducted among poisoned dogs in the Republic of Macedonia. Morphological and histopathological changes in poisoned dogs were investigated for a period of 10 years. The examination was performed on 31 dogs, 13 of which were home kept, 7 were street dogs and 11 of unknown origin. The most significant necropsy findings concerned the inflammatory and necrotic processes of the gastrointestinal tract. The histopathological changes were mainly located in the kidneys, stomach, intestines and the lungs. https://macvetrev.mk/Files/Article/2020/10.2478/macvetrev-2018-0014/macvetrev-2018-0014.pdf 2018-10-15T09:00:00 203 207 10.2478/macvetrev-2018-0014 poisoning dog histopathology welfare Ivica Gjurovski igjurovski@fvm.ukim.edu.mk false 1 Faculty of Veterinary Medicine, Ss Cyril and Methodius University, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of Macedonia LEAD_AUTHOR Monika Dovenska false 2 Faculty of Veterinary Medicine, Ss Cyril and Methodius University, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of Macedonia AUTHOR Aleksandar Janevski false 3 Faculty of Veterinary Medicine, Ss Cyril and Methodius University, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of Macedonia AUTHOR Trpe Ristoski false 4 Faculty of Veterinary Medicine, Ss Cyril and Methodius University, Lazar Pop Trajkov 5-7, 1000 Skopje, Republic of Macedonia AUTHOR Ladislav, N., Jan, M., Alena, H., Petr, O., Kamil, K., Oldřich, V., Václav, R., Petr, C. (2011). Incidental poisoning of animals by carbamates in the Czech Republic. J Appl Biomed. 9, 157–161. 1 10.2478/v10136-009-0035-3 Robertson, I.D., Leggoe, M., Dorling, P.R., Shaw, S.E., Clark, W.T. (1992). A retrospective study of poisoning cases in dogs and cats:comparisons between a rural and an urban practice. Aust. Vet. J. 69 (8):194-195. PMid:1530556 2 10.1111/j.1751-0813.1992.tb07522.x Yingzi, W., Paul, K., Albert, H., Inge, H., Wolf-Dieter, R. (2007). Pesticide poisoning in domestic animals and livestock in Austria:a 6 years retrospective study. Forensic Sci. Int. 169, 157–160. PMid:16997525 3 10.1016/j.forsciint.2006.08.008 Hornfeldt, C.S., Murphy, M.J. (1997). Poisonings of animals:the 1993–1994 report of the American Association of Poison Control Centers, Vet. Hum. Toxicol. 39 (6):361–365. PMid:9397507 4 Gwak, H.S., Noh, E.S., Lee, N.Z., Chun, I.K. (2005). Determination of amosulalolin human plasma using solid-phase extraction combined with liquid chromatography and ultraviolet detection. J. Chromatogr. B. 818, 109–113. PMid:15734149 5 10.1016/j.jchromb.2004.06.029 Goyer R. A., Rhyne B. C. (1973). Pathological effects of lead. Int Rev Exp Pathol. 12, 1-77. PMid:4349348 6 Paşca, S.A., Solcan, Gh., Şindilar, E.V., Lazăr, M. (2012). Clinical and morphopathological aspects in anti-freeze intoxication of dogs. Scientific works. C Series. Veterinary Medicine 58 (4):296-305. 7 O'Malley, M. (1997). Clinical evaluation of pesticide exposure and poisonings. Lancet 349, 1161–1166. 8 10.1016/S0140-6736(96)07222-4 Liddle, J.A., Kimbrough, R.D., Needham, L.L., Cline, R.E., Smrek, A.L., Yert, L.W., Bayse, D.D., Ellington, A.C., Dennis, P.A. (1979). Fatal episode of accidental methomyl poisoning. Clin Toxicol. 15 (2):159-167. PMid:509881 9 10.3109/15563657908989861 Moriya, F., Hashimoto, Y. (2005). A fatal poisoning caused by methomyl and nicotine. Forensic Sci Int. 10, 149 (2-3):167-170 10 10.1016/j.forsciint.2004.06.013 Tsatsakis, A.M., Bertsias, G.K., Mammas, I.N., Stiakakis, I., Georgopoulos, D.B. (2001). Acute fatal poisoning by methomyl caused by inhalation and transdermal absorption. Bull Environ Contam Toxicol. 66 (4):415-420. PMid:11443300 11 10.1007/s001280021 Theerayuth, K., Acharawan, L., Piyawan, C., Supatra, S. (2011). Retrospective histopathological study of hemorrhagic lesion of coumarin intoxication in dogs. Thai J Vet Med. 41 (2):239-244. 12 Jubb K.V.F., Kennedy P.C., Palmer N. (2007). Pathology of domestic animals. In:G. Maxie (Ed), New York:Academic Press. PMCid:PMC1906653 13 Department for Environment, Food and Rural Affairs. (2009). Code of practice for the welfare of dogs. Crown copyright. London 14 Animal welfare and protection law. Official Journal of R.M. 149 (October 13, 2014) 15