CASE_STUDY A one-day-old female Holstein calf was presented with subcutaneous masses spread over the whole body. Macroscopically, the masses were firm in touch, greyish-white in colour, 0.5-2 cm in diameter range. Histopathological examination confirmed the cutaneous Kaposiform hemangioendothelioma (KHE). Microscopic examination of the tumor revealed sheets of spindled endothelial cells forming vascular slits. Immunohistochemically, the tumor cells and capillaries gave strongly positive reaction for CD31 while vimentin, alpha smooth muscle actin and cytokeratin AE1/AE3 were negative. In this case, macroscopical, detailed histhopathological and immunohistochemical findings of congenital KHE reported firstly in a newborn calf. https://macvetrev.mk/Files/Article/2020/10.2478/macvetrev-2020-0018/macvetrev-2020-0018.pdf 2020-10-15T09:00:00 193 196 10.2478/macvetrev-2020-0018 kaposiform hemangioendothelioma pathology immunohistochemistry new-born calf Erkmen Tuğrul Epikmen false 1 Department of Pathology, Faculty of Veterinary Medicine, University of Aydin Adnan Menderes, Aydin, Turkey AUTHOR Ahmet Aydogan aaydogan79@gmail.com false 2 Department of Pathology, Faculty of Ceyhan Veterinary Medicine, University of Çukurova, Adana, Turkey LEAD_AUTHOR Hamdi Avci false 3 Department of Pathology, Faculty of Veterinary Medicine, University of Aydin Adnan Menderes, Aydin, Turkey AUTHOR Sümbül Serap Birincioğlu false 4 Special A Pathology Laboratory, Izmir, Turkey AUTHOR Zukerberg, L.R., Nickoloff, B.J., Weiss, S.W. (1993). Kaposiform hemangioendothelioma of infancy and childhood. An aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis. Am J Surgic Pathol. 17(4): 321-328. PMid:8494101 1 10.1097/00000478-199304000-00001 Tsang, W.Y.W. (2002). Kaposiform hemangioendothelioma. In: Fletcher CDM, Unni KK, Mertens F. (Eds.), World Health Organization classification of tumors: pathology and genetics, tumors of soft tissue and bone (pp. 163-164), Lyon, France: IARC. 2 Lyons, L.L., North, P.E., Mac-Moune Lai, F., Stoler, M.H., Folpe, A.L., Weiss, S.W. (2004). Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic,  immunophenotypic,  and biologic uniqueness from juvenile hemangioma. Am J Surgic Pathol. 28, 559-568. PMid:15105642 3 10.1097/00000478-200405000-00001 Enjolras, O., Wassef, M., Mazoyer, E., Frieden, I.J., Rieu, P.N., Drouet, L., et al. (1997). Infants with Kasebach-Merritt syndrome do not have "true hemangiomas". J Pediatr. 130(4): 631-640. 4 10.1016/S0022-3476(97)70249-X Gianotti, R., Gelmetti, C., Alessi, E. (1999). Congenital cutaneous multifocal kaposiform hemangioendothelioma. Am. J. Dermatopathol. 21(6): 557. PMid:10608250 5 10.1097/00000372-199912000-00010 Vincek, V., Zaulyanov, L., Mirzabeigi, M. (2004). Kaposiform hemangioendothelioma: the first reported case in a nonhuman animal species. Vet Pathol. 41(6): 695-697. PMid:15557080 6 10.1354/vp.41-6-695 Giacomo, R., Livio, G., Sara, B., Maria Assunta, P., Patrizia, R., Timothy, R., Maria Luisa, C. (2016). Neck kaposiform haemangioendothelioma in a Fischer's lovebird (Agapornis fischeri). Res Vet Sci. 106, 112-115. PMid:27234547 7 10.1016/j.rvsc.2016.03.018 Goldschmidt, M.H., Hendrick, M.J. (2002). Tumors of the skin and soft tissues. In: Meuten DJ. (Ed.), Tumors in domestic animals (pp. 102-103). 4th Ed. Ames, USA: Iowa State Press. 8 Vin Christian, K., Mc Calmont, T.H., Frieden, I.J. (1997). Kaposiform hemangioendothelioma. An aggressive, locally invasive vascular  tumor  that  can mimic hemangioma of infancy. Arch Dermatol. 133(12): 1573-1578. PMid:9420544 9 10.1001/archderm.133.12.1573 Debelenko, L.V., Perez-Atayde, A.R., Mulliken, J.B., Liang, M.G., Archibald, T.H., Kozakewich, H.P. (2005). D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. Mod Pathol. 18, 1454-1460. PMid:15920541 10 10.1038/modpathol.3800444 Stratton, J.S., Billings, S.D. (2009). Vascular tumors of intermediate malignancy: a review and update. Dermatologica Sinica 27(3): 140-153. 11 Miettinen, M., Lindenmayer, A.E., Chaubal, A. (1994). Endothelial cell markers CD31, CD34, and BNH9 antibody to  H-  and  Yantigens:  evaluation of their specificity and sensitivity in the diagnosis   of vascular tumors and comparison with von Willebrand factor. Modern Pathol. 7(1): 82-90. 12 De Young, B.R., Frierson, H.F., Micki, N., Smith, D., Swanson, P.E. (1998). CD31 Immunoreactivity in Carcinomas and Mesotheliomas. Am J Clin Pathol. 110(3): 374-377. PMid:9728613 13 10.1093/ajcp/110.3.374