ORIGINAL_ARTICLE Trichosomoides crassicauda (T. crassicauda) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite. https://macvetrev.mk 2021-10-15T09:00:00 159 167 10.2478/macvetrev-2021-0019 nematode parasite rat Trichosomoides crassicauda urinary bladder Vladyslav Sikora v.sikora@med.sumdu.edu.ua false 1 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine LEAD_AUTHOR Mykola Lуndіn false 2 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Natalia Hyriavenko false 3 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Roman Moskalenko false 4 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Yulia Lуndіna false 5 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Kateryna Kateryna false 6 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Ruslana Chyzhma false 7 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Olena Diachenko false 9 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Anatolii Romaniuk false 8 Department of Pathology, Sumy State University, Privokzalna 31, Sumy 40022, Ukraine AUTHOR Akiyama, Y., Homma, Y., Maeda, D. 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