Review Article The addition of antibiotic growth promotors in poultry diets results in a development of resistant bacterial strains and accumulation of drug residues in the meat and eggs. The new trend in poultry industry is the dietary addition of natural feed additives including phytobiotics. Pomegranate (Punica granatum L.) is a natural cheap feed source that has been extensively used in the livestock production. In poultry production system, pomegranate by-products such as peel powder or extract, seed oil, or juice showed high nutritional values, several health benefits, and good economic profits. Pomegranate displays a growth promoting effect and an enhancement of carcass traits of broilers, along with an improvement of the egg production traits parameters. Moreover, dietary pomegranate by-products showed a potential antioxidant and antimicrobial effects on the treated birds. Modulation of both humeral and cell mediated immune response, hypo-lipidemia, as well as enhancement of liver functions have been proved following dietary treatment with different pomegranate by-products. Therefore, this review article was designed to present the different effects of dietary pomegranate by-products on the production indices of broilers and layers, the antioxidant, antimicrobial, and immune status, as well as the blood parameters. https://macvetrev.mk/LoadArticlePdf/361 2023-7-12 113 128 https://doi.org/10.2478/macvetrev-2023-0022 antioxidant chicken immunity performance Punica granatum L Wafaa A. Abd El-Ghany wafaa.soliman@cu.edu.eg false 1 Poultry Diseases Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt LEAD_AUTHOR Abd El-Ghany, W.A. (2020). Paraprobiotics and postbiotics: contemporary and promising natural antibiotics alternatives and their applications in the poultry field. Open Vet J. 10(3): 323-330. 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