ORIGINAL_ARTICLE In the ear of corn there are silky strands which run its length and these strands are known as corn silks. Folk remedies show that the corn silks have been used as an oral antidiabetic agent in China for many years and as herbal tea in other world nations for the amelioration of urinary tract infection. The extract is being assessed for safety in this study using histopathological changes, as well as an electrocardiogram (ECG). Graded doses (200, 400 and 800 mg/kg) of aqueous CS extract were administered to rats for seven days. The fourth group which served as control received 3 ml/kg dose of distilled water. On the eighth day, ECG was evaluated in ketamine/xylazine-induced anaesthesia in rats to determine changes in the heart rate, P-wave duration, P-R interval, R-amplitude, QRS duration, QT interval and QTc. Hearts from the experimental animals were collected for histopathological changes. The results showed that there was a significant change in the heart rate (groups B and C), P-wave duration (group D), QT interval (groups B, C and D) and QTc (groups B, C and D) when compared to the control group. Histology also indicated that sections of the heart showed fatty infiltration of inflamed heart and areas of moderate inflammation of the atrium and ventricle. It could therefore be concluded from this study that though folklore indicated that corn silk (CS) is of high medicinal value, one must be careful in using this product as medicinal agent especially in patients with compromised heart conditions. https://macvetrev.mk/Files/Article/2020/10.1515/macvetrev-2015-0065/macvetrev-2015-0065.pdf 2016-03-15T09:00:00 43 49 10.2478/macvetrev-2015-0065 corn silks ECG histopathology cardiotoxicity rats Adeolu Adedapo aa.adedapo@ui.edu.ng false 1 Department of Veterinary Physiology, Biochemistry and Pharmacology,University of Ibadan, Ibadan, Nigeria LEAD_AUTHOR Omotayo Babarinsa false 2 Department of Veterinary Physiology, Biochemistry and Pharmacology,University of Ibadan, Ibadan, Nigeria AUTHOR Ademola Oyagbemi false 3 Department of Veterinary Physiology, Biochemistry and Pharmacology,University of Ibadan, Ibadan, Nigeria AUTHOR Aduragbenro Adedapo false 4 Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria AUTHOR Temidayo Omobowale false 5 Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria AUTHOR Rao, NK., Nammi, S. 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