ORIGINAL_ARTICLE
Retrospective investigation on the prevalence of pulmonary hypertension in dogs with bronchial and upper respiratory diseases
Bronchial and upper respiratory diseases have been associated with hypoxia and subsequent development of pulmonary arterial hypertension (PAH). However, there are no known studies assessing the prevalence of PAH in dogs with these conditions. The aim of this study was to assess the frequency of PAH in dogs with bronchial and upper respiratory diseases. Medical records of dogs with confirmed diagnosis (by endoscopic examination) of bronchial and/or upper respiratory diseases referred for cardiovascular investigation (January 2009 - May 2013) were retrospectively reviewed. Diagnosis of PAH was made by echocardiography (tricuspid regurgitation > 2.8 m/s and/or pulmonic regurgitation > 2.2 m/s); possible PAH was diagnosed when two or more specific echocardiographic findings were present. 52 dogs (30 with upper respiratory diseases, 17 with bronchial disease and 5 with both) were included. Diagnosis of PAH was performed in 3 dogs (5.7%). Two dogs were considered as probably affected by PAH; a total of 5 dogs (9.4%) resulted in being affected or probably affected by PAH. Our study shows that the prevalence of PAH in dogs with bronchial and/or upper respiratory diseases is low; PAH seems to occur mostly in older dogs and/or with very advanced disease: echocardiography may therefore be a useful tool in this category of patients.
https://macvetrev.mk/Files/Article/2019/10.1515/macvetrev-2016-0075/macvetrev-2016-0075.pdf
2016-03-15T09:00:00
83
90
10.2478/macvetrev-2016-0075
dogs
pulmonary arterial hypertension
respiratory disease
tricuspid regurgitation
Chiara
Locatelli
false
1
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Daniela
Montrasio
false
2
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Ilaria
Spalla
false
3
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Giulia
Riscazzi
false
4
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Matteo
Gobbetti
false
5
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Alice
Savarese
false
6
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Stefano
Romussi
false
7
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
AUTHOR
Paola
G.
Brambilla
paola.brambilla@unimi.it
false
8
Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
LEAD_AUTHOR
Kellihan, H.B., Stepien, R.L. (2010). Pulmonary hypertension in dogs: diagnosis and therapy. Vet Clin Small Anim. 40, 623-641. PMid:20610015
1
10.1016/j.cvsm.2010.03.011
Galiè, N., Hoeper, M., Humbert, M. et al. (2009). Guidelines for the diagnosis and treatment of pulmonary hypertension. European Heart Journal 30, 2493-2537. PMid:19713419
2
10.1093/eurheartj/ehp297
Soydan, L.C., Kellihan, H.B., Bates, L.B., Stepien, R.L., Consigny, D.W., Bellofiore, A., Francois, C.J., Chesler, N.C. (2015). Accuracy of doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension. Journal of Veterinary Cardiology 17, 13 – 24. PMid:25601540
3
10.1016/j.jvc.2014.10.004
Borgeat, K., Sudunagunta, S., Kaye, B., Stern, J., Luis Fuentes, V., Connolly, D. J. (2015). Retrospective evaluation of moderate-to-severe pulmonary hypertension in dogs naturally infected with angiostrongylus vasorum. Journal of Small Animal Practice 56, 196–202. PMid:25483150
4
10.1111/jsap.12309
Johnson, L., Boon, J., Orton, E.C. (1999). Clinical characteristic of 53 dogs with Doppler - derived evidence of pulmonary hypertension 1992–1996. Journal of Veterinary Internal Medicine 13, 440–444. PMid:10499728
5
Kellihan, H.B., Stepien, R.L. (2012). Pulmonary hypertension in canine degenerative mitral valve disease. Journal of Veterinary Cardiology 14,149–164. PMid:22364721
6
10.1016/j.jvc.2012.01.001
Pyle, R.L., Abbott, J., Maclean, H. (2004). Pulmonary hypertension and cardiovascular sequela in 54 dogs”. International Journal of Applied Research in Veterinary Medicine 2, 99–109.
7
Serres, F.J., Chetboul, V., Tissier, R., Sampedrano, C.C., Gouni, V., Nicolle, A.P., Pouchelon, J.L. (2006). Doppler echocardiography-derived evidence of pulmonary arterial hypertension in dogs with degenerative mitral valve disease: 86 cases (2001–2005). Journal of the American Veterinary Medical Association 229, 1772–1778. PMid:17144824
8
10.2460/javma.229.11.1772
Johnson, L.R., Hamlin, R.L. (1995). Recognition and treatment of pulmonary hypertension. In: Bonagura J.R.D. (Ed.), Kirk’s Current Veterinary Therapy XII (pp 887 – 892). Philadelphia USA: WB Saunders.
9
Campbell, F.E. (2007). Cardiac effects of pulmonary disease. Veterinary Clinics North America Small Animal Practice 37. 949-962. PMid:17693208
10
10.1016/j.cvsm.2007.05.006
Mc Laughlin. V.V., Rich. S. (2000). Corpulmonale. In: Braunwald E, Zipes DP, Libby P. (Ed.), Heartdisease: a textbook of cardiovascular medicine. 6th Edition. (pp 1936-1956). Philadelphia USA: WB Saunders.
11
Venco, L., Milhaylova, L., Boon, J.A. (2014). Right pulmonary artery distensibility index (RPAD index). A field study of an echocardiographic method to detect earl development of pulmonary hypertension and its severity even in the absence of regurgitant jets for Doppler evaluation in heartworm-infected dogs. Vet Parasitol. 206, 60-6. PMid:25218885
12
10.1016/j.vetpar.2014.08.016
Swann, J., Sudunagunta, S., Covey, H.L., English, K., Hendricks, A., Connolly, D.J. (2014). Evaluation of red cell distribution width in dogs with pulmonary hypertension. Journal of Veterinary Cardiology 16, 227-235. PMid:25465342
13
10.1016/j.jvc.2014.08.003
Sasaki, Y., Kitagawa, H., Hirano, Y. (1992). Relationship between pulmonary arterial pressure and lesionsin the pulmonary arteries and parenchyma, and cardiac valves in canine dirofilariasis. Journal of Veterinary Medical Science 54, 739–744.
14
10.1292/jvms.54.739
Nicolle, A.P., Chetboul, V., Tessier-Vetzel, D., Sampedrano, C.C., Aletti, E., Pouchelon, J.L. (2006). Severe pulmonary arterial hypertension due to Angiostrongylosu svasorum in a dog. The Canadian Veterinary Journal 47, 792-795. PMid:16933559 PMCid:PMC1524835
15
Traversa, D., Di Cesare, A., Meloni, S., Frangipane di Regalbono, A., Milillo, P., Pampurini, F., Venco, L. (2013). Canine angiostrongylosis in Italy: prevalence of Angiostrongylus vasorum in dogs with compatible clinical pictures. Parasitology Research 112, 2473-2480. PMid:23595212 PMCid:PMC3683398
16
10.1007/s00436-013-3412-5
Borgarelli, M., Abbott, J., Braz-Ruivo, L., Chiavegato, D., Crosara, S., Lamb, K., Ljungvall, I., Poggi, M., Santilli, R.A., Haggstrom, J. (2015). Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine 29, 569–574. PMid:25818210
17
10.1111/jvim.12564
Thomas, W.P., Gaber, C.E., Jacobs, G.J., Kaplan, P.M., Lombard, C.W., Moise, N.S., Moses, B.L. (1993). Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Journal of Veterinary Internal Medicine 7, 247-252.
18
10.1111/j.1939-1676.1993.tb01015.x
Boon, J.A. (1998). Evaluation of size, function and hemodynamics. In: Boon J.A. (Ed.), Manual of veterinary echocardiography (pp. 151–260). Williams & Wilkins Co, Baltimore. PMid:9654462
19
Cooper, J.W., Nanda, N.C., Philpot, E.F., Fan, P. (1989). Evaluation of valvular regurgitation by colour Doppler. Journal of the American Society of Echocardiography 2, 56-66.
20
10.1016/S0894-7317(89)80030-6
Schober, K.E., Baade, H. (2006). Doppler echocardiographic prediction of pulmonary hypertensionin West Highland White Terriers with chronic pulmonary disease. Journal of Veterinary Internal Medicine 20, 912-920.
21
10.1111/j.1939-1676.2006.tb01805.x
Glaus, T., Schnyder, M., Dennler, M., Tschuor, F., Wenger, M., Sieber-Ruckstuhl, N. (2010). Natural infection with Angiostrongylus vasorum: characterisation of 3 dogs with pulmonary hypertension. Schweizer Archiv für,Tierheilkunde152, 331-338. PMid:20582899
22
10.1024/0036-7281/a000076
Estèves, I., Tessier, D., Dandrieux, J., Polack, B., Carlos, C., Boulanger, V., Muller, C., Pouchelon, J.L., Chetboul, V. (2004). Reversible pulmonary hypertension presenting simultaneously with an atrial septal defect and angiostrongylosis in a dog. Journal of Small Animal Practice 45, 206-209. PMid:15116890
23
10.1111/j.1748-5827.2004.tb00226.x
Matos, J. M., Schnyder, M., Bektas, R., Makara, M., Kutter, A., Jenni, S., Deplazes, P., Glaus, T. (2012). Recruitment of arteriovenous pulmonary shunts may attenuate the development of pulmonary hypertension in dogs experimentally infected with Angiostrongylus vasorum. Journal of Veterinary Cardiology 14, 313-322. PMid:22575676
24
10.1016/j.jvc.2012.01.014
Kuehn, N.F. (2003). Chronic bronchitis in dogs. In: L. King (Ed.), Textbook of Respiratory Diseases of the Dog and Cat (pp. 379-387). Philadelphia USA: WB Saunders.
25
Paradies, P., Spagnolo, P.P., Amato, M.E., Pulpito, D., Sassanelli, M. (2014). Doppler echocardiographic evidence of pulmonary hypertension in dogs: a retrospective clinical investigation. Veterinary Research Communication 38, 63-71. PMid:24414341
26
10.1007/s11259-013-9588-4
Herrtage, M.E., White, R. (2000). Management of tracheal collapse. In: J. Bonagura, RD (Ed) Kirk’s Current Veterinary Therapy XIII (pp 796-801). Philadelphia USA: WB Saunders.
27
Hendricks, J.C. (2003). Brachycephalic Airway Syndrome. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 310-318). Philadelphia USA: WB Saunders.
28
Holt, D.E., Brockman, D. (2003). Laryngeal paralysis. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 319-328). Philadelphia USA: WB Saunders.
29
Mason, R.A., Johnson, L.R. (2003). Tracheal collapse. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 346-355). Philadelphia USA: WB Saunders.
30