ORIGINAL_ARTICLE Retrospective investigation on the prevalence of pulmonary hypertension in dogs with bronchial and upper respiratory diseases Bronchial and upper respiratory diseases have been associated with hypoxia and subsequent development of pulmonary arterial hypertension (PAH). However, there are no known studies assessing the prevalence of PAH in dogs with these conditions. The aim of this study was to assess the frequency of PAH in dogs with bronchial and upper respiratory diseases. Medical records of dogs with confirmed diagnosis (by endoscopic examination) of bronchial and/or upper respiratory diseases referred for cardiovascular investigation (January 2009 - May 2013) were retrospectively reviewed. Diagnosis of PAH was made by echocardiography (tricuspid regurgitation > 2.8 m/s and/or pulmonic regurgitation > 2.2 m/s); possible PAH was diagnosed when two or more specific echocardiographic findings were present. 52 dogs (30 with upper respiratory diseases, 17 with bronchial disease and 5 with both) were included. Diagnosis of PAH was performed in 3 dogs (5.7%). Two dogs were considered as probably affected by PAH; a total of 5 dogs (9.4%) resulted in being affected or probably affected by PAH. Our study shows that the prevalence of PAH in dogs with bronchial and/or upper respiratory diseases is low; PAH seems to occur mostly in older dogs and/or with very advanced disease: echocardiography may therefore be a useful tool in this category of patients. https://macvetrev.mk/Files/Article/2019/10.1515/macvetrev-2016-0075/macvetrev-2016-0075.pdf 2016-03-15T09:00:00 83 90 10.2478/macvetrev-2016-0075 dogs pulmonary arterial hypertension respiratory disease tricuspid regurgitation Chiara Locatelli false 1 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Daniela Montrasio false 2 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Ilaria Spalla false 3 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Giulia Riscazzi false 4 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Matteo Gobbetti false 5 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Alice Savarese false 6 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Stefano Romussi false 7 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy AUTHOR Paola G. Brambilla paola.brambilla@unimi.it false 8 Department of Veterinary Sciences and Public Health (DIVET),Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy LEAD_AUTHOR Kellihan, H.B., Stepien, R.L. (2010). Pulmonary hypertension in dogs: diagnosis and therapy. Vet Clin Small Anim. 40, 623-641. PMid:20610015 1 10.1016/j.cvsm.2010.03.011 Galiè, N., Hoeper, M., Humbert, M. et al. (2009). Guidelines for the diagnosis and treatment of pulmonary hypertension. European Heart Journal 30, 2493-2537. PMid:19713419 2 10.1093/eurheartj/ehp297 Soydan, L.C., Kellihan, H.B., Bates, L.B., Stepien, R.L., Consigny, D.W., Bellofiore, A., Francois, C.J., Chesler, N.C. (2015). Accuracy of doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension. Journal of Veterinary Cardiology 17, 13 – 24. PMid:25601540 3 10.1016/j.jvc.2014.10.004 Borgeat, K., Sudunagunta, S., Kaye, B., Stern, J., Luis Fuentes, V., Connolly, D. J. (2015). Retrospective evaluation of moderate-to-severe pulmonary hypertension in dogs naturally infected with angiostrongylus vasorum. Journal of Small Animal Practice 56, 196–202. PMid:25483150 4 10.1111/jsap.12309 Johnson, L., Boon, J., Orton, E.C. (1999). Clinical characteristic of 53 dogs with Doppler - derived evidence of pulmonary hypertension 1992–1996. Journal of Veterinary Internal Medicine 13, 440–444. PMid:10499728 5 Kellihan, H.B., Stepien, R.L. (2012). Pulmonary hypertension in canine degenerative mitral valve disease. Journal of Veterinary Cardiology 14,149–164. PMid:22364721 6 10.1016/j.jvc.2012.01.001 Pyle, R.L., Abbott, J., Maclean, H. (2004). Pulmonary hypertension and cardiovascular sequela in 54 dogs”. International Journal of Applied Research in Veterinary Medicine 2, 99–109. 7 Serres, F.J., Chetboul, V., Tissier, R., Sampedrano, C.C., Gouni, V., Nicolle, A.P., Pouchelon, J.L. (2006). Doppler echocardiography-derived evidence of pulmonary arterial hypertension in dogs with degenerative mitral valve disease: 86 cases (2001–2005). Journal of the American Veterinary Medical Association 229, 1772–1778. PMid:17144824 8 10.2460/javma.229.11.1772 Johnson, L.R., Hamlin, R.L. (1995). Recognition and treatment of pulmonary hypertension. In: Bonagura J.R.D. (Ed.), Kirk’s Current Veterinary Therapy XII (pp 887 – 892). Philadelphia USA: WB Saunders. 9 Campbell, F.E. (2007). Cardiac effects of pulmonary disease. Veterinary Clinics North America Small Animal Practice 37. 949-962. PMid:17693208 10 10.1016/j.cvsm.2007.05.006 Mc Laughlin. V.V., Rich. S. (2000). Corpulmonale. In: Braunwald E, Zipes DP, Libby P. (Ed.), Heartdisease: a textbook of cardiovascular medicine. 6th Edition. (pp 1936-1956). Philadelphia USA: WB Saunders. 11 Venco, L., Milhaylova, L., Boon, J.A. (2014). Right pulmonary artery distensibility index (RPAD index). A field study of an echocardiographic method to detect earl development of pulmonary hypertension and its severity even in the absence of regurgitant jets for Doppler evaluation in heartworm-infected dogs. Vet Parasitol. 206, 60-6. PMid:25218885 12 10.1016/j.vetpar.2014.08.016 Swann, J., Sudunagunta, S., Covey, H.L., English, K., Hendricks, A., Connolly, D.J. (2014). Evaluation of red cell distribution width in dogs with pulmonary hypertension. Journal of Veterinary Cardiology 16, 227-235. PMid:25465342 13 10.1016/j.jvc.2014.08.003 Sasaki, Y., Kitagawa, H., Hirano, Y. (1992). Relationship between pulmonary arterial pressure and lesionsin the pulmonary arteries and parenchyma, and cardiac valves in canine dirofilariasis. Journal of Veterinary Medical Science 54, 739–744. 14 10.1292/jvms.54.739 Nicolle, A.P., Chetboul, V., Tessier-Vetzel, D., Sampedrano, C.C., Aletti, E., Pouchelon, J.L. (2006). Severe pulmonary arterial hypertension due to Angiostrongylosu svasorum in a dog. The Canadian Veterinary Journal 47, 792-795. PMid:16933559 PMCid:PMC1524835 15 Traversa, D., Di Cesare, A., Meloni, S., Frangipane di Regalbono, A., Milillo, P., Pampurini, F., Venco, L. (2013). Canine angiostrongylosis in Italy: prevalence of Angiostrongylus vasorum in dogs with compatible clinical pictures. Parasitology Research 112, 2473-2480. PMid:23595212 PMCid:PMC3683398 16 10.1007/s00436-013-3412-5 Borgarelli, M., Abbott, J., Braz-Ruivo, L., Chiavegato, D., Crosara, S., Lamb, K., Ljungvall, I., Poggi, M., Santilli, R.A., Haggstrom, J. (2015). Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine 29, 569–574. PMid:25818210 17 10.1111/jvim.12564 Thomas, W.P., Gaber, C.E., Jacobs, G.J., Kaplan, P.M., Lombard, C.W., Moise, N.S., Moses, B.L. (1993). Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Journal of Veterinary Internal Medicine 7, 247-252. 18 10.1111/j.1939-1676.1993.tb01015.x Boon, J.A. (1998). Evaluation of size, function and hemodynamics. In: Boon J.A. (Ed.), Manual of veterinary echocardiography (pp. 151–260). Williams & Wilkins Co, Baltimore. PMid:9654462 19 Cooper, J.W., Nanda, N.C., Philpot, E.F., Fan, P. (1989). Evaluation of valvular regurgitation by colour Doppler. Journal of the American Society of Echocardiography 2, 56-66. 20 10.1016/S0894-7317(89)80030-6 Schober, K.E., Baade, H. (2006). Doppler echocardiographic prediction of pulmonary hypertensionin West Highland White Terriers with chronic pulmonary disease. Journal of Veterinary Internal Medicine 20, 912-920. 21 10.1111/j.1939-1676.2006.tb01805.x Glaus, T., Schnyder, M., Dennler, M., Tschuor, F., Wenger, M., Sieber-Ruckstuhl, N. (2010). Natural infection with Angiostrongylus vasorum: characterisation of 3 dogs with pulmonary hypertension. Schweizer Archiv für,Tierheilkunde152, 331-338. PMid:20582899 22 10.1024/0036-7281/a000076 Estèves, I., Tessier, D., Dandrieux, J., Polack, B., Carlos, C., Boulanger, V., Muller, C., Pouchelon, J.L., Chetboul, V. (2004). Reversible pulmonary hypertension presenting simultaneously with an atrial septal defect and angiostrongylosis in a dog. Journal of Small Animal Practice 45, 206-209. PMid:15116890 23 10.1111/j.1748-5827.2004.tb00226.x Matos, J. M., Schnyder, M., Bektas, R., Makara, M., Kutter, A., Jenni, S., Deplazes, P., Glaus, T. (2012). Recruitment of arteriovenous pulmonary shunts may attenuate the development of pulmonary hypertension in dogs experimentally infected with Angiostrongylus vasorum. Journal of Veterinary Cardiology 14, 313-322. PMid:22575676 24 10.1016/j.jvc.2012.01.014 Kuehn, N.F. (2003). Chronic bronchitis in dogs. In: L. King (Ed.), Textbook of Respiratory Diseases of the Dog and Cat (pp. 379-387). Philadelphia USA: WB Saunders. 25 Paradies, P., Spagnolo, P.P., Amato, M.E., Pulpito, D., Sassanelli, M. (2014). Doppler echocardiographic evidence of pulmonary hypertension in dogs: a retrospective clinical investigation. Veterinary Research Communication 38, 63-71. PMid:24414341 26 10.1007/s11259-013-9588-4 Herrtage, M.E., White, R. (2000). Management of tracheal collapse. In: J. Bonagura, RD (Ed) Kirk’s Current Veterinary Therapy XIII (pp 796-801). Philadelphia USA: WB Saunders. 27 Hendricks, J.C. (2003). Brachycephalic Airway Syndrome. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 310-318). Philadelphia USA: WB Saunders. 28 Holt, D.E., Brockman, D. (2003). Laryngeal paralysis. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 319-328). Philadelphia USA: WB Saunders. 29 Mason, R.A., Johnson, L.R. (2003). Tracheal collapse. In: L. King (Ed) Textbook of Respiratory Diseases of the Dog and Cat (pp. 346-355). Philadelphia USA: WB Saunders. 30