ORIGINAL_ARTICLE Since fluoroquinolones are one of the most commonly used antibacterial drugs in aquaculture, there is a risk of their residues to be found in the treated fish. The objective of this study was to examine t he changes in enrofloxacin and ciprofloxacin levelsduring storage of rainbow trout and common carp muscle at -18 °C. The trout and carp were treated orally with a single dose of 10 mg/kg of enrofloxacin. Tissue samples were collected 24 h after the treatment and stored at -18 °C for 270 days either as a whole fish or as precut muscle samples. Results for trout revealed that in the precut samples enrofloxacin concentration decreased significantly only after 9 months of storage, whereas a significant decline in the ciprofloxacin level was observed much earlier (after 3 months). After 9 months of storage, the trout stored without being sliced and eviscerated showed significantly higher levels of both quinolones as compared to the precut muscle samples. The enrofloxacin levels in the carp musculature decreased considerably after 3 months of storage and stayed almost unchanged up to the end of the study, whereas the ciprofloxacin concentration continued to drop even after this period and after 270 days constituted 1/6 of the initial values. https://macvetrev.mk/Files/Article/2019/10.1515/macvetrev-2016-0076/macvetrev-2016-0076.pdf 2016-03-15T09:00:00 97 102 10.2478/macvetrev-2016-0076 ciprofloxacin common carp enrofloxacin rainbow trout residues storage Ralica Kyuchukova ralitsa.kjuchukova@abv.bg false 1 Department of Hygiene and Technology of Foods,Faculty of Veterinary Medicine, Trakia University, Bulgaria LEAD_AUTHOR Anelia Milanova false 2 Department of Pharmacology, Physiology of Animals and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Bulgaria AUTHOR Aleksandra Daskalova false 3 Department of Hygiene and Technology of Foods,Faculty of Veterinary Medicine, Trakia University, Bulgaria AUTHOR Deyan Stratev false 4 Department of Hygiene and Technology of Foods,Faculty of Veterinary Medicine, Trakia University, Bulgaria AUTHOR Lubomir Lashev false 5 Department of Pharmacology, Physiology of Animals and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Bulgaria AUTHOR Alexander Pavlov false 6 Department of Hygiene and Technology of Foods,Faculty of Veterinary Medicine, Trakia University, Bulgaria AUTHOR Currie, D., Lynas, L., Kennedy, D.G., McCaughey, W.J. 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