Original Scientific Article
Comparative study on the pharmacokinetics of inorganic and organic iron compounds in broiler chickens
Dimitrichka Dimitrova
*
,
Anna Arnaudova-Matey
,
Petar Dilov
,
Geno Angelov
,
Tandju Mehmedo
,
Toni Todorov
,
Denka Kushvalieva
,
Dimitrina Nikolova
,
Valija Dilova
Abstract
The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron compounds were injected intravenously in v. brachialis. After a 20-day “wash-out” period the ferrous methionate and ferrous sulphate were administered again by an elastic silicone tube into the crop. The serum concentrations of the iron were determined using a bioanalyser. Two pharmacokinetic approaches were used – compartmental and non-compartmental analysis. After i.v. injection we found statistically significantly longer and better distribution of the iron contained in the ferrous methionate compared to the ferrous sulphate. The AUC0→∞ was statistically significantly higher in the ferrous methionate. In the alimentary tract of broiler chickens, ferrous methionate was absorbed more rapidly than ferrous sulfate. It was also distributed at a higher volume as compared to the ferrous sulfate.
Keywords: pharmacokinetics, ferrous sulphate, ferrous methionate, chickens
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Copyright
© 2014 Dimitrova D. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Conflict of Interest Statement
The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.
Citation Information
Macedonian Veterinary Review. Volume 37, Issue 1, Pages 75-81, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.14432/j.macvetrev.2014.01.008, 2014
10.14432/j.macvetrev.2014.01.008
