Case Report
A clinical case of unilateral ovarian dysgerminoma and pyometra in a bitch
Anton Antonov * ,
Ivan Fasulkov ,
Radostin Simeonov

Mac Vet Rev 2014; 37 (2): 179 - 183

10.14432/j.macvetrev.2014.04.013

Received: 04 February 2014

Received in revised form: 26 February 2014

Accepted: 25 March 2014

Available Online First: 26 April 2014

Published on: 15 October 2014

Correspondence: Anton Antonov, i.fasulkov@gmail.com
PDF HTML

Abstract

A clinical case of an 11-year-old bitch with unilateral ovarian dysgerminoma and pyometra is described. The owner reported purulent discharge from external genitalia, fastidious appetite and depression. Transabdominal ultrasonography of the reproductive organs showed a hypoechoic mass in the region of the left ovary (7.18 × 6.65 cm) and a strongly enlarged uterine lumen full of anechoic fluid. Vaginal cytology demonstrated about 50% superficial cornfield epithelial cells and multiple neutrophils. Complete blood counts and blood biochemistry analysis indicated a significant leukocytosis and a mild anemia. Blood progesterone (3.96 ng/ml) and estradiol (86 pg/ml) were assayed. Median laparotomy revealed an enlarged uterus, substantially altered left ovary, of the size of a grapefruit. The right ovary was of normal size and structure. Tumor metastases in other organs were not seen. Histologically, diffusely located cancer cells resembling primitive germ cells, specific for dysgerminomas, were established. One year after the surgery, according to the owner the dog is vital, with normal appetite and without general condition abnormalities.

Keywords: dysgerminoma, pyometra, bitch, tumors


References

1. Andrews, E.J., Stookey, J.L., Helland, D.R., Slaughter, L.J. (1974). A histopathological study of canine and feline ovarian dysgerminomas. Can J Comp Med. 38: 85-89. PMid:4272962; PMCid:PMC1319972

2. Buergelt, C. (1968). Dysgerminomas in two dogs. J Am Vet Med Assoc. 153: 553-555. PMid:5691153

3. Dehner, L.P., Norris, H.J., Garner, F.M., Taylor, H.B. (1970). Comparative pathology of ovarian neoplasms. III. Germ cell tumors of canine, bovine, feline, rodent and human species. J Comp Pathol. 80: 299-310. PMid: 5449975

4. Diakov, L., Lozanov, L., Stoikov, D. (1989). Manual for veterinary pathohistology. Sofia: Zemizdat. PMid:2697957

5. Dillberger, J.E., Altman, N.H. (1987). A canine ovarian germ cell tumor with extraembryonic differentiation. Vet Pathol. 24: 96-98. PMid:3029938

6. Fernández, T., Díez-Bru, N., Rios, A., Gómez, L., Pumarola, M. (2001). Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog. J Am Anim Hosp Assoc. 37: 553-556. PMid:11716030

7. Greenlee, P.G., Patnaik, A.K. (1985). Canine ovarian tumors of germ cell origin. Vet Pathol. 22: 117-122. PMid:2984828

8. Ishmael, J. (1970). Dysgerminoma of the ovary in a bitch. J Small Anim Pract. 11: 697-701. http://dx.doi.org/10.1111/j.1748-5827.1970.tb07051.x PMid:5533241

9. Jackson, M.L., Mills, J.H.L., Fowler, J.D. (1985). Ovarian dysgerminoma in a bitch. Can Vet J. 26: 285-287. PMid:17422574; PMCid:PMC1680110

10. Johnston, SD, Kustritz, M.V.R., Olson, P.N.S. (2001). Canine and feline theriogenology. Philadelphia: Saunders, pp. 203-205.

11. Kaneko, J.J., Harvey, J.W., Bruss, M. (2008). Clinical biochemistry of domestic animals, 6th ed. Philadelphia: Saunders. http://dx.doi.org/10.1016/B978-0-12-370491-7.00031-3

12. McEntee, M.C. (2002). Reproductive oncology. Clin Tech Small Anim Pract. 17: 133-149. http://dx.doi.org/10.1053/svms.2002.34642 PMid:12476817

13. Novotny, R., Vitasek, R., Bartoskova, A. (2011). Ovarian dysgerminoma with retroperitoneal metastases in a bitch: a case report. Vet Med –Czech, 56: 140-144.

14. Park, J.K., Goo, M.J., Hong, I.H., Ki, M.R., Han, J.Y., Jeong, K.S. (2009). Immunohistochemistry diagnosis of an ovarian dysgerminoma in one bitch. Reprod Dom Anim. 44: 855-858. http://dx.doi.org/10.1111/j.1439-0531.2008.01135.x PMid:18992107

15. Rolim, V.M., Pinto, T.M., de Almeida Lopes, L.M., Sonne, L., de Oliveira, E.C., de Almeida, P.R., de Castro Beck, C.A., Driemeier, D. (2010). Bilateral dysgerminoma and cystic endometrial hyperplasia with pyometra in a bitch. Acta Sci Vet. 38: 337-340.

16. Ververidis, H.N., Boscos, C.M., Stefanakis, A., Saratsis, P., Stamou, A.I., Krambovitis, E. (2004). Serum estradiol-17 β, progesterone and respective uterine cytosol receptor concentrations in bitches with spontaneous pyometra. Theriogenology, 62: 614-623. http://dx.doi.org/10.1016/j.theriogenology.2003.11.011 PMid:15226016

17. Weiss, D.J., Wardrop, K.J. (2010). Schalm’s veterinary hematology, 6th ed. Iowa: Blackwell Publishing.


Copyright

© 2014 Antonov A. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 37, Issue 2, Pages 179-183, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.14432/j.macvetrev.2014.04.013, 2014