Original Scientific Article
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
Neno Bratoev ,
Aneliya Milanova ,
Ivelina Pavlova ,
Lubomir Lashev *

Mac Vet Rev 2016; 39 (2): 219 - 224

10.1515/macvetrev-2016-0086

Received: 14 April 2016

Received in revised form: 23 May 2016

Accepted: 31 May 2016

Available Online First: 24 June 2016

Published on: 15 October 2016

Correspondence: Lubomir Lashev, lashev@uni-sz.bg
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Abstract

The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.

Keywords: doxycycline, ducks, force-feeding, pharmacokinetics

References

1. Pijpers A, Van Klingeren B, Schoevers E.J, Verheijden J.H.M, Van Miert A.S, In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogensJ. Vet. Pharmacol. Ther 1989; 12: 267-276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid: 2810475

2. Anadón A, Martínez-Larra-aga M.R, Diaz M.J, Bringas P, Fernandez M.C, Fernandez-Cruz M.L, Iturbe J, Martínez M.A, Pharmacokinetics of doxycycline in broiler chickensAvian Pathol 1994; 23: 79-90. http://dx.doi.org/10.1080/03079459408418976 PMid: 18671073

3. Poapolathep A, Poapolathep S, Imsilp K, Noonpugdee C, Klangkaew N, Kusujarit N, Tirawattanawanich C, Subsinsoonthon B, Pharmacokinetics and bioavailability of doxycycline in Thai native chickensJ. Thai. Vet. Med. Assoc 2005; 56: 59-65.

4. Yang F, Li G.H, Meng X.B, Wang L.Q, Huang X.H, Shan Q, Zeng D.P, Ding H.Z, Zeng Z.L, Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickensJ. Vet. Pharmacol. Ther 2012; 36: 85-88. http://dx.doi.org/10.1111/j.1365-2885.2012.01382.x PMid: 22292913

5. Küng K, Wanner M, Pharmacokinetics of Doxycycline in turkeys and comparison between feed and water medicationArchiv für Geflügelkunde 1994; 58: 84-88.

6. Santos M.D, Vermeersch H, Remon J, Schelkens M, Backer P, Van Bree H.J, Ducatelle R, Haesebrouck F, Pharmacokinetics and bioavailability of doxycycline in turkeys JVet. Pharmacol. Ther 1996; 19: 274-280. http://dx.doi.org/10.1111/j.1365-2885.1996.atb00049.x

7. Yang F, Sun N, Zhao Z.S, Wang G.Y, Wang M.F, Pharmacokinetics of doxycycline after a single intravenous, oral or intramuscular dose in Muscovy ducks (Cairina moschata)British Poultry Sci 2015; 56: 137-142. http://dx.doi.org/10.1080/00071668.2014.989488 PMid: 25411077

8. Dorrestein G, Weling J, Haagsma N, Pharmacokinetic differences for doxycycline between racing pigeon (Columba livia) and collared doves (Streptopelis decaocto) and the effect of a salmonella infectionVII. Tagung der Fachgroupe “Geflugelkrankheiten” 1990; München, Germany: Verbindung dem Institut für Geflugelkrankheiten der Ludvig-Maximilians-Universitet; 132-143.

9. Bernard P.G, Bengone T, Prehn D, Durand S, Labie C, Benard P, Physiology of ducks during force-feeding: study of hepatic steatosisBulletin de l’Academie Vétérinaire de France 2006; 159: 43-54.

10. Bogin E, Avidar Y, Merom M, Israeli B, Malkinson M, Sobak S, Kudler Y, Biochemical changes associated whit fatty liver in geeseAvian Pathol 1984; 13: 683-901.
http://dx.doi.org/10.1080/03079458408418566 PMid: 18766879

11. Awde S, Marty-Gasset N, Wilkesman J, Remingnon H, Proteolytic activity alterations resulting from force-feeding in Muscovy and Pekin ducksPoultry Sci 2013; 92: 2997-3002. http://dx.doi.org/10.3382/ps.2013-03195 PMid: 24135604

12. Bratoev N, Lashev L, Pharmacokinetics of enrofloxacin in ducks with steatosis after force-feeding 2014; Sofia, Bugaria: VII- conference of the Bulgarian focal center of EFSA, October 2014;

13. Baert K, Croubels S, Gasthuys F, De Busser J, De Backer P, Pharmacokinetics and oral bioavailability of a doxycycline formulation (DOXYCYCLINE 75%) in nonfasted young pigsJ. Vet. Pharmacol. Ther 2001; 23: 45-48.

14. El-Gendi A.Y.I, Aziza M.A, Amer M.M, Kamel G.M, Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pre-treated with either: Diclazuril or HalofuginoneFood and Chem. Toxicol 2010; 48: 3209-3214. http://dx.doi.org/10.1016/j.fct.2010.08.024 PMid: 20736042

15. Yang F, Si H.B, Wang Z.S, Zhao B.H, Zhou B.H, Hao X.Q, Pharmackinetics of doxycycline in laying hens after intravenous and oral administrationBritsh poultry sci 2016; http://dx.doi.org/10.1080/00071668.2016.1184228 PMid: 27137900

16. Bengone-Ndong T, Benard G, Prehn D, Colas E, Grimm F, Benard P, Etude de la cinetique de la bromosulfonephthaleine et du vert d’indocyanine chez le canard: determination de la lineariteRevue. Méd. Vét 1996; 147: 75-80.

17. Slana M, Pahor V, CvitkovičMaričič L, Sollner-Dolenc M, Excretion pattern of enrofloxacin after oral treatment of chicken broilers 2014; 37: 611-614.
http://dx.doi.org/10.1111/jvp.12130

18. Buechler C, Weiss T.S, Does hepatic steatosis affect drug metabolizing enzymes in the liver?Curr. Drug Metab 2011; 12: 24-34. http://dx.doi.org/10.2174/138920011794520035

19. Liu Y, Ramamurthy N, Marecek J, Lee H.M, Chen J.L, Ryan M.E, Rifkin B.R, Golub L.M, The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs)Curr. Med. Chem 2001; 8: 243-252. http://dx.doi.org/10.2174/0929867013373525 PMid: 11172678

20. Mckellar Q, Sanchez Bruni ASF, Jones D.G, Pharmacokinetic /pharmacodynamic relationships of antimicrobial drugs used in veterinary medicineJ. Vet. Pharmacol. Therap 2004; 27: 503-514. http://dx.doi.org/10.1111/j.1365-2885.2004.00603.x PMid: 15601444

Copyright

© 2016 Bratoev N. This is an open-access article publishedunder the terms of the Creative Commons Attribution License whichpermits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 39, Issue 2, Pages 219-224, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.1515/macvetrev-2016-0086, 2016

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.