Macedonian Veterinary Review

Short Communication

Acute oral toxicity of Vetom 21.77 based on Duddingtonia Flagrans in broiler chickens

Elmira R. Rafikova *

Mac Vet Rev 2019; 42 (1): 87 - 93

10.2478/macvetrev-2018-0031

Received: 02 March 2018

Received in revised form: 12 July 2018

Accepted: 18 September 2018

Available Online First: 30 December 2018

Published on: 15 March 2019

Correspondence: Elmira R. Rafikova, pchelka_leta@mail.ru

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Abstract

A 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus Duddingtonia flagrans. A total of 40 healthy 5-day-old broiler chickens (Hubbard F15, 100 ± 5 g), that had previously gone through a required 5-days adaptation to the environment, were orally dosed with the drug for 5 consecutive days at different doses, after which their health status was assessed daily up to the end of the experiment. According to the results, no substantial changes in the physiological state of the chickens were detected during the experiment. Internal organs weighing revealed no statistically significant differences between the groups, though weight coefficient values of internal organs of treated chickens slightly exceeded those of the control group. Some haematological parameters were significantly higher in the treatment group, without going beyond reference ranges. All chickens used in the experiment survived the study. The preparation has not produced any toxic effect even at a higher dose (4000 µL/kg bw/day). It is concluded that Vetom 21.77 pertains to preparations of IV toxicity class.

Keywords: Vetom 21.77, Duddingtonia flagrans, acute toxicity, Hubbard F15

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Copyright

© 2018 Rafikova E. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Acknowledgment

The author is grateful to her scientific supervisor, Professor G. A. Nozdrin, for his remarkable guidance and assistance throughout this work. I would like to express my deepest appreciation to Sergey Kozhevnikov for Russian to English translation. I also acknowledge the efforts of the entire team of Veterinary Research Laboratory of Agrotechnopark at Shakarim state University.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 42, Issue 1, Pages 83-93, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.2478/macvetrev-2018-0031, 2018