Short Communication
Acute phase proteins – As indicators of claw diseases in dairy cattle
Ksenija Ilievska * ,
Branko Atanasov ,
Toni Dovenski ,
Ozren Smolac ,
Boris Stojanov ,
Plamen Trojachanec

Mac Vet Rev 2019; 42 (1): 95 - 100

10.2478/macvetrev-2019-0011

Received: 03 June 2018

Received in revised form: 21 November 2018

Accepted: 28 December 2018

Available Online First: 04 February 2019

Published on: 15 March 2019

Correspondence: Ksenija Ilievska, kilievska@fvm.ukim.edu.mk
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Abstract

The serum concentration of certain acute phase proteins significantly increases during various pathological conditions in cattle. The aim of this study was to determine the influence of claw disorders etiology on the concentrations of two major acute phase proteins in dairy cattle: haptoglobin (Hp) and serum amyloid protein A (SAA). Fifty dairy cows with claw pathology were included. Fourteen clinically healthy heifers served as controls. The animals were subdivided in 5 groups according to the pathological findings on their claws: 1. Heel horn erosion (HE), 2. Acute laminitis (AL), 3. Sole ulcer (SU), 4. Digital dermatitis (DD) and 5. White line separation (WLS). Hp and SAA concentrations were measured in serum samples using commercial ELISA kits. Higher concentrations of both Hp and SAA were found in the AL and SU groups (p<0.01) compared to the HE, DD and WLS and control groups. Dairy cows in the DD group had higher (p<0.05) Hp and SAA concentrations than the HE and WLS groups and the controls. The serum values between the HE, WLS and the control group did not differ significantly. The presented results indicate that the claw diseases are associated with a systemic acute phase response. Hp and SAA could be used as valuable biomarkers for early detection of claw diseases in dairy cows.

Keywords: haptoglobin, serum amyloid A protein, dairy cattle, claw disease

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Copyright

© 2019 Ilievska K. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Acknowledgment

The authors would like to thank the colleagues from Dairy farms ZK Pelagonija, Radobor and Porodin for their help in conducting this research.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 42, Issue 1, Pages 95-100, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.2478/macvetrev-2019-0011, 2019

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.