Case Report
Mammary adenocarcinoma with widespread metastasis in a lion (Panthera leo)
Ivica Gjurovski * ,
Monika Dovenska ,
Slavica Kostadinova Kunovska ,
Jordanco Milosevski ,
Vesna Levajkovic Trajkov ,
Trpe Ristoski

Mac Vet Rev 2019; 42 (2): 195 - 199

10.2478/macvetrev-2019-0019

Received: 17 April 2019

Received in revised form: 01 July 2019

Accepted: 10 July 2019

Available Online First: 20 July 2019

Published on: 15 October 2019

Correspondence: Ivica Gjurovski, igjurovski@hotmail.com
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Abstract

A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.

Keywords: carcinoma, mammary gland, lion

References

  1. Vail, D. M., Mac Ewen, E.G. (2000). Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest. 18(8): 781-792. https://doi.org/10.3109/07357900009012210  PMid:11107448
  2. Misdorp, W. (2002). Tumors of the mammary gland. In: Meuten DJ. (Ed.), Tumors in domestic animals (pp. 575- 606). 4th ed. Ames, USA: Iowa State Press. https://doi.org/10.1002/9780470376928.ch12
  3. Schmidt, R. E., Langham, R. F. (1967). A survey of feline neoplasms. J Am Vet Med Assoc. 151, 1325- 1328.
  4. Hayden, D. W., Nielsen, S. W. (1971). Feline mammary tumors. J Small Anim Pract. 12, 687-698. https://doi.org/10.1111/j.1748-5827.1971.tb06197.x PMid:4335377
  5. Weijer, K., Head, K. W., Misdorp, W., et al. (1972). Feline malignant mammary tumors. I. Morphology and biology: some comparisons with human and canine mammary carcinomas. J Natl Cancer Inst. 49, 1697-1704. https ://doi.or g/10.1093/jnci/49.6.1697 PMid:4346020
  6. Ryan, A. S., Linden, E. C., Edward, C. R., Kelly H., Darin C., Michael, M. G. (2016). Clinicopathologic features of mammary masses in captive lions (Panthera Leo). Journal of Zoo and Wildlife Medicine 47(1): 127-131. https://doi.or g/10.1638/2015-0087.1 PMid:27010273
  7. Gilette, D. M., Acland, H. M., Klein, L. (1991). Ductular mammary carcinoma in a lioness. J Am Vet Med Assoc. 173, 1099-1102.
  8. Misdorp, W., Else, R. W., Hellmen, E., et al. (1999). Histological classification of mammary tumors of the dog and the cat. 2nd ed. Washington, USA: Armed Forces Institute of Pathology 3-29.
  9. Misdorp, W., Cotchin, E., Hampe, J. F., et al. (1971). Canine malignant mammary tumors: I. Sarcomas. Vet Pathol. 8(2): 99-117. https://doi.org/10.1177/030098587100800202 PMid:4367432
  10. Fox, D. B., Cook, J. L., Kreeger, J. M., Beissenherz, M., Henry, C. J. (2002). Canine synovial sarcoma: a retrospective assessment of described prognostic criteria in 16 cases (1994-1999). J Am Anim Hosp Assoc. 38, 347- 355. https://doi.org/10.5326/0380347 PMid:12118688
  11. Niveditha, S. R, Bajaj, P. (2003). Vimentin expression in breast carcinomas. Indian J Pathol Microbiol. 46, 579- 584.
  12. Hemalatha, A., Suresh, T. N., Harendra, K. M. L. (2013). Expression of vimentin in breast carcinoma, its correlation with Ki-67 and other histopathological parameters. Indian J Cancer. 50, 189-194. https://doi.org/10.4103/0019-509X.118724 PMid:24061457
  13. Lian T. L., Guan, J., Qian, C., Jun, N. Z. (2015). Ki- 67 is a promising molecular target in the diagnosis of cancer. Mol Med Rep.11, 1566-1572. https://doi.org/10.3892/mmr.2014.2914 PMid:25384676
  14. Cagnini, D. Q., Salgado, B. S., Linardi, J. L., Grandi, F., Rocha, R. M., Rocha, N. S., Teixeira, C. R., Del Piero, F., Sequeira, J. L. (2012). Ocular melanoma and mammary mucinous carcinoma in an African lion. BMC Veterinary Research 8, 176. https://doi.org/10.1186/1746-6148-8-176 PMid:23009723 PMCid:PMC3517319
  15. Sonmez, G., Aytug, N., Akkoc, A., Cihan, H., Alasonyalilar, A. (2018). Intestinal adenocarcinoma with diffuse peritoneal carcinomatosis in a lion (Panthera leo). Eur J Wildl Res. 54, 385-389. https://doi.org/10.1007/s10344-007-0151-x
  16. Riccardi, E., Greco, V., Verganti, S., Finazzi, M. (2007). Immunohistochemical diagnosis of canine ovarian epithelial and granulosa cell tumors. J Vet Diagn Invest. 19, 431-435. https://doi.org/10.1177/104063870701900418 PMid:17609358
  17. Toniti, P., Sirivisoot, S., Jandee, P., Srimontri, P., Puchadapirom, P., Doungchawee, G., Kasorndorkbua, C. (2010). AE1/AE3, Vimentin and p63 Immunolocalization in canine mammary gland tumours: roles in differentiation between luminal epithelial and myoepithelial lineages. Asian Pac. J. Cancer Prev. 11, 227-230.
  18. Aydogan, A., Metin, N. (2013). Detection of cell origin by immunohistochemistry in canine mammary tumours. Revue Méd. Vét. 164, 7, 395- 399.
  19. Caliari, D., Zappulli, V., Rasotto, R., Cardazzo, B., Frassineti, F., Goldschmidt, M. H., Castagnaro, M. (2014). Triple-negative vimentin-positive heterogeneous feline mammary carcinomas as a potential comparative model for breast cancer. BMC Vet Res. 10, 185. https://doi.org/10.1186/s12917-014-0185-8 PMid:25249140 PMCid:PMC4180584
  20. Karabolovski, N., Gudan Kurilj, A., Severin, K., Hohsteter, M., Sostaric Zuckermann, I.- C., Medveny, L., Artuković, B., Grabarevic, Z. (2016). Immunohistochemical study of epithelial- mesenchymal transition in feline mammarytumours. Journal of Comparative Pathology 154(1): 114. ttps://doi.org/10.1016/j.jcpa.2015.10.145

Copyright

© 2019 Gjurovski I. This is an open-access article publishedunder the terms of the Creative Commons Attribution License whichpermits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 42, Issue 2, Pages 195-199, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2019-0019, 2019

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.