Case Report
Mammary adenocarcinoma with widespread metastasis in a lion (Panthera leo)
Ivica Gjurovski*,
Monika Dovenska,
Slavica Kostadinova Kunovska,
Jordanco Milosevski,
Vesna Levajkovic Trajkov,
Trpe Ristoski

Mac Vet Rev 2019; 42 (2): 195 - 199


Received: 17 April 2019

Received in revised form: 01 July 2019

Accepted: 10 July 2019

Available Online First: 20 July 2019

Published on: 15 October 2019

Correspondence: Ivica Gjurovski,


A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.

Keywords: carcinoma, mammary gland, lion


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© 2019 Gjurovski I. This is an open-access article publishedunder the terms of the Creative Commons Attribution License whichpermits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 42, Issue 2, Pages 195-199, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2019-0019, 2019