Case Report
Uterine leiomyosarcoma associated with cystic endometrial polyps, chondriod metaplasia and uterine horn intussusception in a greater cane rat (Thryonomys swinderianus)
Olusola Lawrence Ajayi*,
Moshood Olajire Olaniyi,
Olugbenga Olayinka Alaka,
Richard Edem Antia,
Temitope Morenikeji Oladipo

Mac Vet Rev 2020; 43 (2): 197 - 204


Received: 05 November 2019

Received in revised form: 05 March 2020

Accepted: 20 April 2020

Available Online First: 29 May 2020

Published on: 15 October 2020

Correspondence: Olusola Lawrence Ajayi,


A rare case of uterine leiomyosarcoma associated with chondriod metaplasia, cystic endometrial polyps and uterine horn intussusception in a greater cane rat was macroscopically, histopathologically, immuno-histochemically and ultrastructurally evaluated. The histopathological findings for this tumour were similar to those for leiomyosarcomas described in other species. Immunohistochemical examination demonstrated positive immunoreactivity of neoplastic cells with α-smooth muscle actin, desmin and vimentin. Ultrastructurally, nuclear and cytoplasmic features were consistent with leiomyosarcoma. These results revealed the tumour to be of smooth muscle origin. To our knowledge, this is the first reported case of uterine leiomyosarcoma associated with cystic endometrial polyps, chondriod metaplasia and uterine horn intussusception in a greater cane rat.

Keywords: uterine leiomyosarcoma, endometrial polyps, chondriod metaplasia, uterine horn intussusception, Greater cane rat


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© 2020 Ajayi O.L. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 43, Issue 2, Pages 197-204, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2020-0019, 2020