Case Report
Uterine leiomyosarcoma associated with cystic endometrial polyps, chondriod metaplasia and uterine horn intussusception in a greater cane rat (Thryonomys swinderianus)
Olusola Lawrence Ajayi*,
Moshood Olajire Olaniyi,
Olugbenga Olayinka Alaka,
Richard Edem Antia,
Temitope Morenikeji Oladipo

Mac Vet Rev 2020; 43 (2): i - viii

10.2478/macvetrev-2020-0019

Received: 05 November 2019

Received in revised form: 05 March 2020

Accepted: 20 April 2020

Available Online First: 29 May 2020

Published on: 15 October 2020

Correspondence: Olusola Lawrence Ajayi, alabsola@yahoo.com

Abstract

A rare case of uterine leiomyosarcoma associated with chondriod metaplasia, cystic endometrial polyps and uterine horn intussusception in a greater cane rat was macroscopically, histopathologically, immuno-histochemically and ultrastructurally evaluated. The histopathological findings for this tumour were similar to those for leiomyosarcomas described in other species. Immunohistochemical examination demonstrated positive immunoreactivity of neoplastic cells with α-smooth muscle actin, desmin and vimentin. Ultrastructurally, nuclear and cytoplasmic features were consistent with leiomyosarcoma. These results revealed the tumour to be of smooth muscle origin. To our knowledge, this is the first reported case of uterine leiomyosarcoma associated with cystic endometrial polyps, chondriod metaplasia and uterine horn intussusception in a greater cane rat.

Keywords: uterine leiomyosarcoma, endometrial polyps, chondriod metaplasia, uterine horn intussusception, Greater cane rat


References

  1. Jori, F., Cooper, J.E., Casal, J. (2001a). Postmortem findings in captive cane rats (Thryonomys swinderianus) in Gabon. Veterinary Record 148(20): 624-628. https://doi.org/10.1136/vr.148.20.624 PMid:11394798
  2. Jori, F., Cooper, J.E. (2001b). Spontaneous neoplasms in captive african cane rats (Thryonomys swinderianus Temminck, 1827). Vet. Pathol. 38, 556-558. https://doi.org/10.1354/vp.38-5-556 PMid:11572565
  3. Mozzachio, K., Linder, K., Dixon, D.  (2004). Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model. Toxicol Pathol. 32, 402-407. https://doi.org/10.1080/01926230490440880 PMid:15307213
  4. Bagley, R.S., Levy, J.K., Malarkey, D.E. (1996). Hypoglycemia associated with intra- abdominal leiomyoma and leiomyosarcoma in six dogs. J Am Vet Med Assoc. 208(1): 69-71.
  5. Mumba, C., Pandey, G.S., Kabali, E., Shibahara, T., Kubo, M. (2011). Uterine fibroleiomyoma in a 12 year old sow. Indian J Vet Pathol. 35(1): 84-86.
  6. Sapundzhiev, E., Pupaki D., Zahariev P., Georgiev G., Ivanov I., (2007). Fibroleiomyoma in elephant uterus. J Vet Med Series A. 54 (9): 499-500. https://doi.org/10.1111/j.1439-0442.2007.00949.x PMid:17931224
  7. Pringproa, K., Madarame, H., Sritun, J., Bumpenpol, P., Pedsri, P., Somgird, C. Thitaram, C. (2015). Histopathological and immunohistochemical characterization of spontaneous uterine leiomyomas in two captive Asian Elephants. Thai J Vet Med. 45(2): 289-294.
  8. Assikis, V.J., Neven, P., Jordan, V.C., Vergote, I. (1996). A realistic clinical perspective of tamoxifen and endometrial carcinogenesis. Eur J Cancer. 32A(9): 1464-1476. https://doi.org/10.1016/0959-8049(96)00184-0
  9. Walsh, K.M., Poteracki, J. (1994). Spontaneous neoplasms in control Wistar rats. Fundam Appl Toxicol. 22(1): 65-72. https://doi.org/10.1093/toxsci/22.1.65
  10. Meuten, D.J. (2002). Tumors in domestic animals. 4th ed. (p.788). Iowa State: University of California. https://doi.org/10.1002/9780470376928
  11. Silva, A.E., Ocarino, N.M., Cassali, G.D., Nascimento, E.F., Coradini, M.A., Serakides, R. (2006). Uterine leiomyoma in chimpanzee (Pan troglodytes). Arq Bras Med Vet Zootec. 58(1): 129- 132. https://doi.org/10.1590/S0102-09352006000100020
  12. Terasaki, M., Terasaki, Y., Yoneyama, K., Kuwahara, N., Wakamatsu, K., Nagahama, K., Kunugi, S., Takeshita, T., Shimizu A.  (2015). Uterine leiomyosarcoma with osteoclast-like giant cells associated with high expression of receptor activator of nuclear factor κB- ligand. Hum Pathol. 46(11): 1679-1684. https://doi.org/10.1016/j.humpath.2015.04.018 PMid:26315618
  13. Chassy, L.M., Gardner, I.A., Plotka, E.D., Munson L. (2002). Genital tract smooth muscle tumors are common in zoo felids but are not associated with melengestrol acetate contraceptive treatment. Vet Pathol. 39(3): 379-385. https://doi.org/10.1354/vp.39-3-379 PMid:12014502
  14. Verkauf, B.S. (1992). Myomectomy for fertility enhancement and preservation. Fertil Steril. 58(1): 1-15. https://doi.org/10.1016/S0015-0282(16)55128-0
  15. Moody, K.D., Weir, E.C., Morgenstern, S.E., Barthold S.W. (1996). Resumption of fertility after myomectomy for uterine leiomyoma in a rhesus macaque. Lab Anim Sci. 46(1): 120- 122.
  16. Santschi, E.M., Slone, D.E. (1994). Successful pregnancy after partial hysterectomy in two mares.  J Am Vet Med Assoc. 205(8): 1180-1182.
  17. Joel, R. L., Micheal, P. J. (1990). Oviduct, uterus, and vagina. In: G.A. Boorman, S. L. Eustis, M. R. Elwell (Eds.), Pathology of the Fischer rat - Reference and atlas (pp. 443459). San Diego: Academic Press.
  18. Anisimov, V. N., Nikonov, A. A. (1990). Tumours  of the vagina, uterus and oviduct. In : V.S. Turusov, U. Mohr (Eds.), Pathology of tumours in laboratory animals (pp. 445-471). Oxford: Oxford University Press.
  19. Cooper, B.J., Valentine, B.A. (2002). Tumors of muscles. In : D. J. Meuten, (Ed), Tumor in domestic animals (pp. 319-363). Ames: Iowa State Press. https://doi.org/10.1002/9780470376928.ch6 PMid:18246071
  20. Tirumani, S.H., Deaver, P., Shinagare, A.B., Tirumani, H., Hornick, J.L., George, S.,    Ramaiya, N.H. (2014).              Metastatic            pattern   of          uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients. J Gynecol Oncol. 25(4): 306-312. https://doi.org/10.3802/jgo.2014.25.4.306 PMid:25142630 PMCid:PMC4195301
  21. Bartosch, C., Mariana, A. Ana, S., Pires, L., Galaghar, A., Guimaraes,  M.  Antunes,  L.J., Lopes, M. (2017). Distant metastases in uterine leiomyosarcomas: the wide variety of body sites and time intervals to metastatic relapse. Int J Gynecol Pathol. 36(1): 31-41. https://doi.org/10.1097/PGP.0000000000000284 PMid:27015437
  22. Ochi, F., Furuno, K., Chong, P., Tezuka, J., Mizuno, Y., Aoki, T., Ishii, E. (2017). Bilateral hydronephrosis due to obstructive ureteral stone associated with norovirus gastroenteritis. Clinical  Case  Reports 5(6): 936-938. https://doi.org/10.1002/ccr3.952 PMid:28588843 PMCid:PMC5458008
  23. Kuroda, K., Osaki, T., Harada, K., Yamashita, M., Murahata, Y., Azuma, K., Tsuka, T., Ito, N., Imagawa, T., Okamoto, Y. (2017). Uterine torsion in  a full-term pregnant cat. JFMS Open Reports. 3(2). https://doi.org/10.1177/2055116917726228 PMid:28839948 PMCid:PMC5564926
  24. Proulx, G., Keith, M., Neil, M., Benjamin, P. (2009). Uterine prolapse in an adult Richardson's ground squirrel (Spermophilus richardsonii). Canadian Field-Naturalist. 123(4): 370-371. https://doi.org/10.22621/cfn.v123i4.1006
  25. Ajayi, O.L., Antia R.E., Omotainse, S.O. (2008). Oviductal volvulus in a Nera black chicken (Gallus gallus domesticus) in Nigeria. Avian Pathol. 37(2): 139-140. https://doi.org/10.1080/03079450801895324 PMid:18393090
  26. Ajayi, O.L., Antia, R.E. (2010). Oviductal lymphangiectasia secondary to mesosalphinx leiomyoma in a chicken (Gallus gallus domesticus) - a case report. Vet Arhiv. 80(1): 155-161.
  27. Yi, J.Y., Kim, Y.H., Yoon, B.I. (2008). Primary subcutaneous leiomyosarcoma of the hamster hind leg. J Vet Med Sci. 70(5): 517-520. https://doi.org/10.1292/jvms.70.517 PMid:18525178
  28. Jeon, B.S., Kim, H.G., Lee, B.W., Han, J.H., Yoon, B.I. (2013). Uterine leiomyosarcoma in a wild rat (Rattus norvegicus): usefulness of Ki-67 labeling index for diagnosis. Lab Anim Res. 29(2): 127-130. https://doi.org/10.5625/lar.2013.29.2.127 PMid:23825485 PMCid:PMC3696625
  29. Vemireddi, V., Ingeborg, M., Langohr, H., Thacker, L. (2007). Polypoid uterine leiomyosarcomas in a sheep. J Vet Diagn Invest. 19(3): 309-312. https://doi.org/10.1177/104063870701900316 PMid:17459865


Copyright

© 2020 Ajayi O.L. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 43, Issue 2, Pages i-viii, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2020-0019, 2020