Original Scientific Article
Evaluation of the therapeutic effects of serratiopeptidase in chicks
Ahmed S. Naser * ,
Yasser M. Albadrany

Mac Vet Rev 2024; 47 (2): 115 - 122

10.2478/macvetrev-2024-0021

Received: 12 March 2024

Received in revised form: 15 July 2024

Accepted: 24 July 2024

Available Online First: 14 August 2024

Published on: 15 October 2024

Correspondence: Ahmed S. Naser, ahmadphd0@gmail.com
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Abstract

Serratiopeptidase is a zinc-containing metalloprotease primarily obtained from Serratia marcescens isolated from the silkworm guts. This study aimed to assess the antinociceptive, anti inflammatory, and antipyretic effects of serratiopeptidase in hen chicks. It included 104 hen chicks weighing 70-90 g. The antinociception efficacy was assessed by electricalstimulation and hot water test. Anti-inflammatory efficacy was assessed by formalin test. Assessment of therapeutic and antipyretic efficacy was determined by Baker’s yeast-induced pyrexia test. In the electrical stimulation test, 20 and 40 mg/kg of serratiopeptidase induced an antinociceptive effect in 15% and 18%, respectively. In the hot-water test, this effect was observed in 31 and 82%, respectively. In the first phase of the formalin test, an antinociceptive effect was observed for both doses, whereas in the second stage, an anti-inflammatory effect was observed in 56% and 62%, respectively. Serratiopeptidase produced a novel antipyretic effect for both doses on the Baker’s-yeast test, pre- and post-injection of the yeast. It was concluded that serratiopeptidase had good activity against pain and acute inflammation, and for the first time, it was demonstrated that serratiopeptidase ameliorated and prevented hyperthermia.

Keywords: serratiopeptidase, protective, fever, chicks, analgesic

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Copyright

© 2024 Naser A.S. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Conflict of Interest Statement

The authors declared that they have no potential lict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 47, Issue 2, Pages 115-122, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2024-0021

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.