Original Scientific Article
Estimate of toxically influence of silicon carbide nanoparticles according histopatologycal changes
Ristoski Trpe
*
,
Vasilevska Violeta
,
Mladenovska Kristina
,
Grozdanov Anita
Received: 23 May 2013
Received in revised form: 27 June 2013
Accepted: 05 July 2013
Available Online First: 15 March 2013
Published on: 15 March 2013
Correspondence: Ristoski Trpe, tristoski@fvm.ukim.edu.mk
Abstract
Taking in consideration a very wide application of nanoparticules in different industrial sectors due to their remarkable properties for implementation in different products, very important part for future development of nanotechology is following a histopatologycal changes provoke of this material. Silicon carbide (SiC) as ceramic material with high thermal conductivity, high stability, good wear resistance and small thermal expansion coefficient is very applied in ceramic’s industry, power electronics, biomaterials, pharmaceutics etc. Histopathological changes of SiC particles were investigate on 4 weeks old female Wistar rats divided into four groups (two control and two experimental groups), sacrificed 2, 7 and 14 days after treatment. Histopathological diagnosis was performed on heart, liver, spleen, kidneys, lung, brain, gastrointestinal tract, using standard Hematoxilin-eosin staining methods. The main toxicological influences of SiC were observed on liver, lungs and gastrointestinal tract.
Keywords: nanoparticules, SiC, toxicity, histopathology
Citation Information
Macedonian Veterinary Review. Volume 36, Issue 1, Pages 25-31, p-ISSN 1409-7621, e-ISSN 1857-7415, 2013
616-092-06.620.3].599.323.4.084
