Original Scientific Article
Estimate of toxically influence of silicon carbide nanoparticles according histopatologycal changes
Ristoski Trpe * ,
Vasilevska Violeta ,
Mladenovska Kristina ,
Grozdanov Anita

Mac Vet Rev 2013; 36 (1): 25 - 31

616-092-06.620.3].599.323.4.084

Received: 23 May 2013

Received in revised form: 27 June 2013

Accepted: 05 July 2013

Available Online First: 15 March 2013

Published on: 15 March 2013

Correspondence: Ristoski Trpe, tristoski@fvm.ukim.edu.mk
PDF HTML

Abstract

Taking in consideration a very wide application of nanoparticules in different industrial sectors due to their remarkable properties for implementation in different products, very important part for future development of nanotechology is following a histopatologycal changes provoke of this material. Silicon carbide (SiC) as ceramic material with high thermal conductivity, high stability, good wear resistance and small thermal expansion coefficient is very applied in ceramic’s industry, power electronics, biomaterials, pharmaceutics etc. Histopathological changes of SiC particles were investigate on 4 weeks old female Wistar rats divided into four groups (two control and two experimental groups), sacrificed 2, 7 and 14 days after treatment. Histopathological diagnosis was performed on heart, liver, spleen, kidneys, lung, brain, gastrointestinal tract, using standard Hematoxilin-eosin staining methods. The main toxicological influences of SiC were observed on liver, lungs and gastrointestinal tract.

Keywords: nanoparticules, SiC, toxicity, histopathology


References


Citation Information

Macedonian Veterinary Review. Volume 36, Issue 1, Pages 25-31, p-ISSN 1409-7621, e-ISSN 1857-7415, 2013