Original Scientific Article
Pharmacokinetics of ciprofloxacin in broiler chickens after single intravenous and intraingluvial administration
Sofiya Ivanova ,
Dimitrichka Dimitrova * ,
Metodi Petrichev

Mac Vet Rev 2017; 40 (1): 67 - 72

10.1515/macvetrev-2017-0013

Received: 09 June 2016

Received in revised form: 12 December 2016

Accepted: 12 January 2017

Available Online First: 01 February 2017

Published on: 15 March 2017

Correspondence: Dimitrichka Dimitrova, dj.dimitrova.56@gmail.com
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Abstract

The trial was performed on 10 clinically healthy Ross hybrid chickens, 5 from each gender, weighing 2.75-2.84 kg. The tested quinolone was applied at the same dose for both routes of application - 10 mg/kg of body weight. Ciprofloxacin hydrochloridum 5% solution for i.v. and 1% solution for intraingluvial treatment were prepared. In a crossover study design, ciprofloxacin hydrochloridum was administered as 5 % solution for i.v. bolus injection to broiler chickens and after 14 days as 1 % solution for intraingluvial administration into a crop to the same birds. Serum ciprofloxacin concentrations were assayed by HPLC with UV detection at a wavelength of 279 nm. After intravenous injection the following pharmacokinetic parameters were determined: t1/2b = 9.07 h; t1/2b= 0.36 h; MRT = 10.20 h and MRT = 10.75 h; AUC0→∞= 19.560 mg.h/mL and AUC0→∞ = 19.843 mg.h/mL. After intraingluvial application parameters determined by the two pharmacokinetic models were as: t1/2a= 0.86 h; t1/2b = 7,20 h and t1/2b = 7.89 h; MRT = 12.67 h and MRT = 12.93 h; AUC0→∞ = 11.340 mg.h/mL and AUC0→24h= 11.973 mg.h/mL; Cmax = 2.841 mg/mL and Cmax = 2.638 mg/mL; Tmax = 0.48 h and Tmax = 0.39 h; t1/2abs. = 0.146 h; MAT = 2.47 h and MAT = 2.18 h; F = 57.91% and F = 63.89%. These results suggested that a dose of 10 mg/kg of body weight provides maximum plasma concentration ater intraingluvial administration and is effective in the control of many infectious diseases of poultry.

Keywords: ciprofloxacin, pharmacokinetics, chickens

References

1. Hannan PCT, O’Hanlon PJ, Rogers NH, In vitro evaluation of various quinolone antibacterial agents against veterinary mycoplasmas and porcine respiratory bacterial pathogensResearch in Veterinary Science 1989; 46: 202-211.PMid:2704885

2. Prescott J, Yielding KH, In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin and norfloxacinCanadian Journal of Veterinary Research 1990; 54: 195-197.

3. Neer TM, Clinical pharmacologic features of fluoroquinolone antimicrobial drugsJournal of American Veterinary Medical Association 1988; 193: 577-580.

4. Vancustem PM, Babish JG, Schwark WS, The fluoroquinolone antimicrobials, clinical use in domestic animals and toxicityCornell Veterinarian 1990; 80: 173-186.

5. Gellert M, DNA topoisomerasesAnnual Reviews of Biochemistry 1981; 50: 879-910. https://doi.org/10.1146/annurev.bi.50.070181.004311 PMid:6267993

6. Nouws JFM, Mevius DJ, Vree TB, Baars AM, Laurensen J, Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigsVeterinary Quarterly 1988; 10: 156-163. https://doi.org/10.1080/01652176.1988.9694165 PMid:3176294

7. Walker RD, Stein GE, Hauptman JG, MacDonald KH, Budsberg SC, Rosser EJ, JrSerum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogsAmerican Journal of Veterinary Research 1990; 51: 896-900.

8. Parikh V, Shivprakash K, Patel D, Gandhi TP, Patel RB, Santani DD, Effect of aspirin on single and multiple dose pharmacokinetics of ciprofloxacin in rabbitsIndian Journal of Pharmacology 1996; 28: 1025-28.

9. Atta AH, Sharif L, Pharmacokinetics of ciprofloxacin folowing intravenous and oral administration in broiler chickensJournal of Veterinary Pharmacology and Therapeutics 1997; 20: 326-329. https://doi.org/10.1046/j.1365-2885.1997.00065.x

10. Nouaille-Degorce B, Veau C, Dautrey S, Tod M, Laouari D, Carbon C, Farinotti R, Influence of renal failure on ciprofloxacin pharmacokinetics in ratsAntimicrobial Agents and Chemotherapy 1998; 42: 289-292.

11. García Ovando H, Gorla N, Luders C, Poloni G, Errecalde C, Prieto G, Puelles I, Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in chickensJournal of Veterinary Pharmacology and Therapeutics 1999; 22: 209-212. https://doi.org/10.1046/j.1365-2885.1999.00211.x

12. Anadón A, Martínez-Larraňaga MR, Iturbe J, Martínez MA, Díaz MJ, Frejo MT, Martínez M, Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickensResearch in Veterinary Science 2001; 71: 101-109. https://doi.org/10.1053/rvsc.2001.0494 PMid:11883887

13. Bashir S, Pharmacokinetics of Ciprofloxacin in Normal and Different Metabolically Altered Conditions in RabbitsPhD Thesis 2007; Pakistan: University College of Pharmacy, University of the Punjab Lahore;

14. Siefert HM, Maruhn D, Maul W, Förster D, Ritter W, Pharmacokinetics of ciprofloxacinArzneimittelforschung Drug Research 1986; 36: 1496-1502.

15. Imre S, Dogaru MT, Vari CE, Muntean T, Kelemen L, Validation of an HPLC method for the determination of ciprofloxacin in human plasmaJournal of Pharmaceutical and Biomedical Analysis 2003; 33: 125-130. https://doi.org/10.1016/S0731-7085(03)00151-1

16. Heinzel G, Wolszcak R, Tomann P, TopFit®2.0. Pharmacokinetic and pharmacodynamic data analysis for the PC1993; Gustav Fisher Verlag, Stuttgart, Germany:

17. Gibaldi M, Perrier D, Gibaldi M, Perrier D, Noncompartimental analysis based on the statistical moment theoryPharmacokinetics 2007; 2nd ed. New York, USA: Revised and Expanded, Informa Healthcare Inc; 409-419.

18. Yamaoka K, Nakagava T, Uno T, Application of Akaike¢s information criterion (AIC) in the evaluation of linear pharmacokinetic equationsJournal of Pharmacokinetics and Biopharmaceutics 1978; 6: 166-171. https://doi.org/10.1007/BF01117450

19. Raina R, Prawez S, Dimitrova DJ, Verma PK, Pankaj NK, Pharmacokinetics of ciprofloxacin following intravenous administration in WLH chikens (Gallus domesticus)Journal of Veterinary Pharmacology and Toxicology 2007a; 6: 6-11.

20. Raina R, Prawez S, Pankaj NK, Verma PK, Pharmacokinetics of ciprofloxacin after single oral administration to WLH chicken (Gallus domesticus)Tamilnadu Journal of Veterinary and Animal Sciences 2007b; 3: 254-259.

Copyright

© 2017 Ivanova S. This is an open-access article publishedunder the terms of the Creative Commons Attribution License whichpermits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 40, Issue 1, Pages 67-72, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.1515/macvetrev-2017-0013, 2017

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.