Macedonian Veterinary Review

Original Scientific Article

Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons

Natalia Francisca Urzúa Pizarro * ,

Carlos Alberto Errecalde ,

Guillermo Fermin Prieto ,

Carlos Fernando Lüders ,

María Paula Tonini ,

Eduardo Jesús Picco

Mac Vet Rev 2017; 40 (2): 143 - 147

10.1515/macvetrev-2017-0019

Received: 12 December 2016

Received in revised form: 10 March 2017

Accepted: 24 March 2017

Available Online First: 10 June 2017

Published on: 15 October 2017

Correspondence: Natalia Francisca Urzúa Pizarro, nurzuapizarro@ayv.unrc.edu.ar

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Abstract

The purpose of this study was to evaluate the differences in the disposition and plasma pharmacokinetic behavior of marbofloxacin (MAR) in broiler chickens at different seasons. Chicken broilers (n = 345) were used, in lots of 5 individuals, divided into 6 groups depending on the way of administration, intravenous or oral (dose 2 mg/kg) and the test period. Post-administration plasma samples were obtained at different times, intravenously (0.08 to 24 hours) and orally (0.25 to 120 hours). A liquid-liquid extraction of MAR was performed by high-performance liquid chromatography (HPLC) with a fluorescent detector. The plasma concentrations obtained at the different sampling times of each season, were analyzed with ANOVA and pharmacokinetic analysis was conducted with the PK Solution 2.0 software. The concentration of marbofloxacin in plasma was significantly lower in winter and summer than in spring, with MAR being detected in winter up to 72 hours post-application, coinciding with the differences in MAR pharmacokinetics parameters with increase in the average residence time (MRT) is 9.4 hours in winter. Increased clearance MAR in summer (7.5 ml/min/kg) coincides with MRT 6.3 hours. Finally, the oral bioavailability of MAR is lower in summer and winter (86 ± 1.7% and 78 ± 3.1%) than in spring (94 ± 5.2 %). There are differences in the disposition and plasma pharmacokinetic behavior of MAR applied orally in broiler chickens, coinciding with the physiological changes in the thermoregulation of birds, considering its correct therapeutic management and contributing to provide safe food for human consumption.

Keywords: pharmacokinetics, marbofloxacin, chickens, seasons changes

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Copyright

© 2017 Pizarro N. This is an open-access article publishedunder the terms of the Creative Commons Attribution License whichpermits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 40, Issue 2, Pages 143-147, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.1515/macvetrev-2017-0019, 2017