Review Article
The oocyte´s nucleolus precursor body: The globe for life
Michal Benc * ,
Lazo Pendovski ,
Matej Murin ,
Frantisek Strejcek ,
Martin Morovic ,
Radek Prochazka ,
Jozef Laurincik

Mac Vet Rev 2018; 41 (2): 115 - 122

10.2478/macvetrev-2018-0013

Received: 28 November 2017

Received in revised form: 27 January 2018

Accepted: 12 February 2018

Available Online First: 31 March 2018

Published on: 15 October 2018

Correspondence: Michal Benc, benc.michal@gmail.com
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Abstract

The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into a dense sphere with no ribosome synthesis well in advance of ovulation. It seems, that this body is of utmost importance for the development of the embryo. It is unknown, however, how it exerts this essential function. During the last two decades, great attention has been paid to the study of nucleogenesis in oocytes and early embryos, with transcription of ribosomal DNA being evaluated as one of the criteria of normal development. In this review, we summarize some aspects of nucleolus transformation during oocyte growth, as well as during early embryonic development with possible impact on the quality of the embryos used in biomedical research. This knowledge in connection with further observations will substantially contribute to the development of new criteria suitable for evaluation of oocytes and embryos used in biomedical application.

Keywords: nucleolus precursor body, oocyte, embryo, transcriptomics, epigenetics

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Copyright 

©2018 Benc M. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Acknowledgement

This work was supported by Slovak Research and Development Agency under the contract No. APVV-14-0001, and also by the projects CZ.02.1.01/0.0/0.0/15_003/0000460, VEGA 1/0022/15, VEGA 1/0327/16 and Research Center AgroBioTech built in accordance with the project Building Research Centre „AgroBioTech” ITMS 26220220180. JF Jr. is supported from GACR 17-08605S.

Conflict of Interest Statement

The authors declared that they have no potential conflict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 41, Issue 2, Pages 115-122, p-ISSN 1409-7621, e-ISSN 1857-7415, DOI: 10.2478/macvetrev-2018-0013, 2018

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.