Original Scientific Article
Study of correlations between clinical signs and morphological features identified in dogs affected with inflammatory bowel disease
David Farray ,
Francisco Rodriguez ,
Yaiza Muñoz-Aznar ,
Antonio G. Ravelo-García ,
José Raduan Jaber *

Mac Vet Rev 2020; 43 (1): 13 - 22

10.2478/macvetrev-2019-0027

Received: 02 March 2019

Received in revised form: 30 September 2019

Accepted: 02 December 2019

Available Online First: 19 December 2019

Published on: 15 March 2020

Correspondence: José Raduan Jaber, joseraduan.jaber@ulpgc.es
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Abstract

This paper evaluates possible relations between the clinical activity and the histopathological findings of the entire intestine in dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 64 dogs of different sex and breed diagnosed with IBD were evaluated. The results of this study did not show a statistically significant correlation between clinical activity and the histopathological assessment of dogs with IBD. Certain connections were found between diarrhea and lacteal dilation in duodenum, and hematochezia and villous epithelial injury in colon but no other associations were found between the rest of the lesions and symptoms.

Keywords: dog, IBD, lesion, clinical signs

References

  1. Jergens, A.E., Schreiner, C.A., Dagmar, E.F., Yosiya, N., Franklin, E.A., Eckersall, P.D., Benson, T.J., Evans, R.A. (2003). Scoring Index for disease activity in canine inflammatory bowel disease. J Vet Intern Med. 17, 291-297. https://doi.org/10.1111/j.1939-1676.2003.tb02450.x PMid:12774968
  2. Craven, M., Simpson, J.W., Ridyard, A.E., Chandler, M.L. (2004). Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J Small Anim Pract. 45, 336-342. https://doi.org/10.1111/j.1748-5827.2004.tb00245.x PMid:15266855
  3. Allenspach, K., Steiner, J.M., Shah, B.N., Berghoff, N., Ruaux, C., Williams, D.A., Blum, J.W., Gaschen, F. (2006). Evaluation of gastrointestinal permeability and mucosal absorptive capacity in dogs with chronic enteropathy. Am J Vet Res. 67, 479-483. https://doi.org/10.2460/ajvr.67.3.479 PMid:16506911
  4. Allenspach, K., Wieland, B., Gröne, A., Gaschen, F. (2007). Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med. 21, 700-708. https://doi.org/10.1111/j.1939-1676.2007.tb03011.x PMid:17708389
  5. Simpson, K.W., Jergens, A.E. (2011). Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin Small Anim. 41, 381-398. https://doi.org/10.1016/j.cvsm.2011.02.003 PMid:21486642
  6. Rychlik, A., Nieradka, R., Kander, M., Nowicki, M., Wdowiak, M., Kolodziejska-Sawerska, A. (2012). A correlation between the canine inflammatory bowel disease activity index score and the histopathological evaluation of the small intestinal mucosa in canine inflammatory bowel disease. Pol J Vet Sci. 15, 315-321. https://doi.org/10.2478/v10181-012-0093-4 PMid:22844710
  7. García-Sancho, M., Rodríguez-Franco, F., Sainz, A., Mancho, C., Rodríguez, A. (2007). Evaluation of clinical, macroscopic and histopahologic response to treatment in non hypoproteinemic dogs with limphocytic-plasmacytic enteritis. J Vet Intern Med. 21, 11-17. https://doi.org/10.1111/j.1939-1676.2007.tb02922.x PMid:17338144
  8. Washabau, R.J., Day, M.J., Willard, M.D., Hall, E.J., Jergens, A.E., Mansell, J., Minami, T., Bilzer, T.W. (2010). Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. ACVIM Consensus statement. J Vet Intern Med. 24,10-26. https://doi.org/10.1111/j.1939-1676.2009.0443.x PMid:20391635
  9. Jergens, A.E. (2004). Clinical assessment of disease activity for canine inflammatory bowel disease. J Am Anim Hosp Assoc. 40, 437-445. https://doi.org/10.5326/0400437 PMid:15533963
  10. Jergens, A.E., Evans, R.B., Ackerman, M., Hostetter, J., Willard, M., Mansell, J., et al. (2014). Design of a simplified histopathologic model for gastrointestinal inflammation in dogs. Vet Pathol. 51 (5): 946- 950. https://doi.org/10.1177/0300985813511123 PMid:24280943
  11. German, A.J., Hall, E.J., Day, M.J. (2001). Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med. 15, 14-25. https://doi.org/10.1111/j.1939-1676.2001.tb02292.x PMid:11215906
  12. Münster, M., Horauf, A., Bilzer, T. (2006). Assessment of disease severity and outcome of dieatary, antibiotic and immunosuppressive interventions by use of the canine IBD activity index in 21 dogs with chronic inflammatory bowel disease. Berl Munch Tierarztl Wochenschr. 119, 493-505.
  13. Day, M.J., Bilzer, T., Mansell, J., Wilcock, B., Hall, E.J., Jergens, A., et al. (2008). Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the world small animal veterinary association gastrointestinal standardization group. J Comp Path. 138, S1-S43. https://doi.org/10.1016/j.jcpa.2008.01.001 
  14. Allenspach, K.A., Mochel, J.P., Du, Y., Priestnall, S.L., Moore, F., Slayter, M., et al. (2019). Correlating gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet Pathol. 56, 435-443. https://doi.org/10.1177/0300985818813090 PMid:30563436
  15. Willard, M., Mansell, J. (2011). Correlating clinical activity and histopathologic assessment of gastrointestinal lesion severity: current challenges. Vet Clin North Am Small Anim Pract. 41, 457-463. https://doi.org/10.1016/j.cvsm.2011.01.005 PMid:21486647
  16. Willard, M.D., Moore, G.E., Denton, B.D., Day, M.J., Mansell, J., Bilzer, T., et al. (2010). Effect of tissue processing on assessment of endoscopic intestinal biopsies in dogs and cats. J Vet Intern Med. 24, 84-89. https://doi.org/10.1111/j.1939-1676.2009.0432.x PMid:20002551
  17. Pierce, E.S. (2018). Could Mycobacterium avium subspecies paratuberculosis cause Crohn's disease, ulcerative colitis and colorectal cancer? Infect Agent Cancer. 13, 1. https://doi.org/10.1186/s13027-017-0172-3 PMid:29308085 PMCid:PMC5753485
  18. Heilmann, R. M., Suchodolski, J. S. (2015). Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization? Vet Immunol Immunopathol. 168(3-4): 131-134. https://doi.org/10.1016/j.vetimm.2015.10.008 PMid:26672910
  19. Prinsen, C.A.C., Mokkink, L.B., Bouter, L.M., Alonso, J., Patrick, D.L., De Vet, HC., et al. (2018). COSMIN guideline for systematic reviews of patient-reported outcome measures. Qual Life Res. 27(5): 1147-1157. https://doi.org/10.1007/s11136-018-1798-3 PMid:29435801 PMCid:PMC5891568

Copyright

© 2019 Farray D. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 43, Issue 1, Pages 13-22, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2019-0027, 2020

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.