Case Report
Congenital cutaneous kaposiform hemangioendothelioma in a newborn calf
Erkmen Tuğrul Epikmen,
Ahmet Aydogan*,
Hamdi Avci,
Sümbül Serap Birincioğlu

Mac Vet Rev 2020; 43 (2): i - iv


Received: 23 December 2019

Received in revised form: 24 March 2020

Accepted: 30 March 2020

Available Online First: 28 May 2020

Published on: 15 October 2020

Correspondence: Ahmet Aydogan,


A one-day-old female Holstein calf was presented with subcutaneous masses spread over the whole body. Macroscopically, the masses were firm in touch, greyish-white in colour, 0.5-2 cm in diameter range. Histopathological examination confirmed the cutaneous Kaposiform hemangioendothelioma (KHE). Microscopic examination of the tumor revealed sheets of spindled endothelial cells forming vascular slits. Immunohistochemically, the tumor cells and capillaries gave strongly positive reaction for CD31 while vimentin, alpha smooth muscle actin and cytokeratin AE1/AE3 were negative. In this case, macroscopical, detailed histhopathological and immunohistochemical findings of congenital KHE reported firstly in a newborn calf.

Keywords: kaposiform hemangioendothelioma, pathology, immunohistochemistry, new-born calf


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© 2020 Aydogan A. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 43, Issue 2, Pages i-iv, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2020-0018, 2020