Original Scientific Article
Disseminated intravascular coagulation syndrome as a complication in acute spontaneous canine babesiosis
Oksana A. Dubova ,
Diana V. Feshchenko ,
Tetiana I. Bakhur * ,
Oksana A. Zghozinska ,
Anatoliy A. Antipov ,
Serhii V. Rublenko ,
Volodymyr P. Goncharenko ,
Raisa V. Shahanenko ,
Volodymyr S. Shahanenko

Mac Vet Rev 2020; 43 (2): 141 - 149

10.2478/macvetrev-2020-0027

Received: 15 October 2019

Received in revised form: 04 July 2020

Accepted: 05 August 2020

Available Online First: 10 September 2020

Published on: 15 October 2020

Correspondence: Tetiana I. Bakhur, fly_13@ukr.net
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Abstract

The polyetiological syndrome of disseminated intravascular coagulation (DIC) is characterized by changes in patients’ hemostasis. The aim of the current research was to elucidate the main factors for the development of DIC syndrome during canine babesiosis, and to assess their correlation level. Dogs included in this study were of various breeds and sex, weighing 10-40 kg and aged 2-7 years. They were separated in two groups (n=50) according to their diagnosis to babesiosis. Oscillometry (blood pressure, pulse rate), vascular-platelet hemostasis, coagulogram, hematological, biochemical (fibrinogen, fibrin degradation product, soluble fibrin-monomer complex) and hemodynamic (circulating blood volume) assessment methods were used. The group of dogs positive on Babesia spp., had clear manifestation of DIC with 5-7% of the erythrocyte population being affected. DIC was manifested by a significant increase in soluble fibrin-monomer complex and fibrin degradation product (p<0.001), hypofibrinogenemia (p<0.001), thrombocytopenia (p<0.001), and an increase in indicators of spontaneous aggregation ability of platelets and red blood cells (p<0.001). Significant hemodynamic disorders were observed: a decrease in circulating blood volume, circulating erythrocytes volume (p<0.05), specific circulating blood volume and hematocrit value (p<0.001). The average blood pressure was reduced (p<0.001), and the Allgöwer’s shock index was increased 2 times (p<0.05). A shock of II degree (medium, subcompensated) was confirmed. Therefore, it can be concluded that acute spontaneous dogs’ babesiosis can be characterized by the occurrence of DIC in a consumption coagulopathy form, and shock of II degree. This condition renders the patients for emergency admission.

Keywords: disseminated intravascular coagulation, babesiosis, dogs, shock, coagulopathy, hemostasis

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Copyright

© 2020 Dubova O.A. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 43, Issue 2, Pages 141-149, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2020-0027, 2020

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.