Original Scientific Article
Morphological peculiarities of parasitic (Trichosomoides crassicauda) infection in rat urinary bladder
Vladyslav Sikora*,
Mykola Lуndіn,
Natalia Hyriavenko,
Roman Moskalenko,
Yulia Lуndіna,
Kateryna Sikora,
Ruslana Chyzhma,
Olena Diachenko,
Anatolii Romaniuk

Mac Vet Rev 2021; 44 (2): 159 - 167


Received: 03 February 2021

Received in revised form: 02 April 2021

Accepted: 26 April 2021

Available Online First: 02 July 2021

Published on: 15 October 2021

Correspondence: Vladyslav Sikora, v.sikora@med.sumdu.edu.ua


Trichosomoides crassicauda (T. crassicauda) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite.

Keywords: nematode, parasite, rat, Trichosomoides crassicauda, urinary bladder


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© 2021 Sikora V. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors have declared that no competing interests exist.

Citation Information

Macedonian Veterinary Review. Volume 44, Issue 2, Pages 159-167, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2021-0019, 2021