Original Scientific Article
Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease
Hande Sağoğlu ,
Remzi Gönül * ,
Lora Koenhemsi ,
Emine Merve Alan ,
Suzan Murat ,
Ashkan Seddigh Nia ,
Mehmet Erman Or

Mac Vet Rev 2023; 46 (1): 61 - 67


Received: 29 August 2022

Received in revised form: 18 January 2023

Accepted: 21 February 2023

Available Online First: 01 March 2023

Published on: 15 March 2023

Correspondence: Remzi Gönül, gonul@iuc.edu.tr


Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the formation of fatal arrhythmias such as torsades de pointes. A fast and accurate assessment is therefore essential. The study aimed to examine the changes in QT duration in MMVD cases of CKCS and to calculate the corrected QT durations with Bazett’s formula in various stages of the disease. The study included 20 CKCS dogs of both genders, various ages and weights, and different stages of MMVD (n=6 in B1 stage, n=6 in B2 stage, and n=8 in C stage), and 5 healthy CKCS which were included in the control group. Clinical, radiological, hematological, biochemical, echocardiographic, and electrocardiographic examinations were performed. The corrected QT interval duration in the MMVD group was longer than the control (p<0.05). However, there was no significant difference between B1, B2, and C. It was concluded that the corrected QT interval can give a significant distinction between healthy and MMVD CKCS dogs.

Keywords: Cavalier, myxomatous, mitral valve, QT


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© 2023 Sağoğlu H. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Conflict of Interest Statement

The authors declared that they have no potential lict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 46, Issue 1, Pages 61-67, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2023-0014, 2023