Original Scientific Article
Active role of lactoferrin on arsenic and imidacloprid toxicity in broiler chicks
Marwa Fouad Hassan ,
Asmaa Gamal Abd El Monsef ,
Nermin Farouq El Zohairy ,
Sanaa Mohamed Salem ,
Safaa Mohamed Elmesalamy ,
Hamada Mahmoud Yousif * ,
Mogda Kamel Mansour

Mac Vet Rev 2024; 47 (2): 167 - 178

10.2478/macvetrev-2024-0028

Received: 10 May 2024

Received in revised form: 25 August 2024

Accepted: 26 August 2024

Available Online First: 02 October 2024

Published on: 15 October 2024

Correspondence: Hamada Mahmoud Yousif, hamadayousif82@gmail.com
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Abstract

This work aimed to evaluate the lactoferrin (LF) effect on arsenic (As) and imidacloprid (IMI) toxicity in broiler chicks. One-week old broiler chicks (n=105) were divided into seven groups (x15 each). The animals were orally supplemented with As, IMI, and/or LF for 4 weeks as follows: Control (G1) no supplements, G2 supplemented with As, G3 supplemented with IMI, G4 supplemented with As+IMI, G5 supplemented with As+LF, G6 supplemented with IMI+LF, G7 supplemented with As+IMI+LF. Body weight and weight gain were recorded on weekly interval. Blood, serum, liver, kidney, and muscle samples were collected at the end of the experimental period for biochemical and histopathological examination. Body weight performance, hematological, serum, and liver tissue biochemical analysis revealed adverse changes in G2, G3, and G4 compared to control, G5, G6, and G7. There was higher tissue residue of As and IMI in G4 compared to G5, G6, and G7. Liver histopathological changes in the groups supplemented with As and/or IMI were observed with necrosis, congestion, and inflammatory cell aggregates. The use of LF in broiler chicks improves weight gain performance and modulates the adverse effects of As and/or IMI toxicity.

Keywords: lactoferrin effect, arsenic toxicity, imidacloprid toxicity, histopathology, broilers chicks

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© 2024 Hassan M.F. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Conflict of Interest Statement

The authors declared that they have no potential lict of interest with respect to the authorship and/or publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 47, Issue 2, Pages 167-178, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI: 10.2478/macvetrev-2024-0028

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