Original Scientific Article
The impact of micellar Coenzyme Q10 and liposomal Coenzyme Q10 on TNF-α and IL-1β in cisplatin
Icko K. Gjorgoski ,
Emilija Shikole ,
Marija Glavas Dodov ,
Majlinda Ademi ,
Elena Rafailovska ,
Dushko Shalabalija ,
Valdrina Ajeti ,
Dimche Zafirov ,
Jasmina Trojachanec ,
Marija Cvijanovikj

Mac Vet Rev 2026; 49 (1): i - vi

10.2478/macvetrev-2026-0013

Received: 08 May 2025

Received in revised form: 22 August 2025

Accepted: 15 October 2025

Available Online First: 25 February 2026

Published on: 15 March 2026

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Abstract

Cisplatin is a widely used chemotherapeutic agent, but its clinical application is often limited due to its nephrotoxic effects, largely mediated through proinflammatory cytokines. This study investigates the comparative effectiveness of micellar and liposomal formulations of Coenzyme Q10 (CoQ10) in modulating serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in a rat model of cisplatin-induced nephrotoxicity. Ninety Wistar rats were divided into control group and five experimental groups receiving various treatments, including cisplatin alone, micellar CoQ10, liposomal CoQ10, and combinations thereof. Serum concentrations of TNF-α and IL-1β were measured at defined intervals using ELISA. The results demonstrated that both formulations of CoQ10 significantly reduced cytokine levels compared to cisplatin-only treated rats, with the liposomal form yielding superior anti-inflammatory effects. These findings suggest that liposomal CoQ10 may offer a more effective strategy for mitigating inflammation and nephrotoxicity induced by cisplatin.

Keywords: Coenzyme Q10, cisplatin-induced nephrotoxicity, TNF-alpha, IL-1 beta, rats

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Copyright

©2026 Gjorgoski I.K. This is an open-access article published under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Conflict of Interest Statement

The authors declared that they have no financial or non-financial conflict of interest regarding authorship and publication of this article.

Citation Information

Macedonian Veterinary Review. Volume 49, Issue 1, Pages i-vi, e-ISSN 1857-7415, p-ISSN 1409-7621, DOI:  https://doi.org/10.2478/macvetrev-2026-0013

The all content of the Macedonian Veterinary Review, except where otherwise noted, is licensed under a Creative Commons Attribution License.