Drug sensitivity was studied of 123 coagulase-positive and coagulase-negative Staphylococcal strains isolated from goats with subclinical mastiti s. MIC was determined by duble seri al dilutions on solid media after Ericsson et al (2). The folowing drugs were used: penicillin, oxicillin, ampicillin, amoxicillin, cefazolin, cefapirin, cefalexin, ceftriaxon, tetracyclin, norfloxacine and ciprofloxacin. Resistance was establi shed against the classical antibiotics penicillin, tetracyclin and tysolin and to some ceph alospirins. Results indicate thet for successful medication of mastitis in goats with ready pharmaceutical drugs the following preparations can be used: gentamicin, third generation cephalosporins, tubocin and fluoroquinolins.