Minimum inhibitory concentration (MIC) of the antibiotics Pn, Oxi, Am, Amx, Clp, Cfl. Cft, Gm, Sm, Km, Tc, T, R, and the fluoroquinulin s E,N,C were determinated in 94 Staph. aureus strains iso lated from women with vaginitis, cows with acuatc endometritis and subclinical mastitis and goats with subclinical mastitis. The resistance to penicillin is 100% and to tetracyclin and tylosin is 60-70%. Staphylococci isolated from women are resistant to large number of antibiotics. The strains isolated from both animals and women are however highly sensitive to cephelotriaxon, gentamicin and fluoroquinulins, with MIC from 0.5 to 4~tg/ml.